Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

Physical activity provides clinical benefit in Parkinson's disease (PD). Irisin is an exercise-
induced polypeptide secreted by skeletal muscle that crosses the blood–brain barrier and …

Adult neurogenesis, the process by which neurons are generated in certain areas of the
adult brain, declines in an age-dependent manner and is one potential target for extending …

Parkinson's disease (PD) is the second most common neurodegenerative disorder and the
fastest growing neurologic disease in the world, yet no disease-modifying therapy is …

Background The aggregation and spread of α-synuclein (α-Syn) protein and related
neuronal toxicity are the key pathological features of Parkinson's disease (PD) and Lewy …

Parkinson's disease (PD) is an incurable, devastating disorder that is characterized by
pathological protein aggregation and neurodegeneration in the substantia nigra. In recent …

The pathological aggregation of the presynaptic protein α-synuclein (α-syn) and propagation
through synaptically coupled neuroanatomical tracts is increasingly thought to underlie the …

Selective vulnerability of specific brain regions and cell populations is a hallmark of
neurodegenerative disorders. Mechanisms of selective vulnerability involve neuronal …

Aberrant accumulation of misfolded proteins into amyloid deposits is a hallmark in many age-
related neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's …