Signaling pathways and defense mechanisms of ferroptosis
J Liu, R Kang, D Tang - The FEBS journal, 2022 - Wiley Online Library
As a type of lytic cell death driven by unrestricted lipid peroxidation and subsequent plasma
membrane damage, ferroptosis occurs and develops because of sophisticated signals and …
membrane damage, ferroptosis occurs and develops because of sophisticated signals and …
Organelle-specific regulation of ferroptosis
Ferroptosis, a cell death modality characterized by iron-dependent lipid peroxidation, is
involved in the development of multiple pathological conditions, including ischemic tissue …
involved in the development of multiple pathological conditions, including ischemic tissue …
Ferroptosis in infection, inflammation, and immunity
Ferroptosis is a type of regulated necrosis that is triggered by a combination of iron toxicity,
lipid peroxidation, and plasma membrane damage. The upstream inducers of ferroptosis …
lipid peroxidation, and plasma membrane damage. The upstream inducers of ferroptosis …
Cathepsin B in programmed cell death machinery: mechanisms of execution and regulatory pathways
Z Xie, M Zhao, C Yan, W Kong, F Lan… - Cell Death & …, 2023 - nature.com
Cathepsin B (CatB), a cysteine protease, is primarily localized within subcellular endosomal
and lysosomal compartments. It is involved in the turnover of intracellular and extracellular …
and lysosomal compartments. It is involved in the turnover of intracellular and extracellular …
A ferrocene‐functionalized covalent organic framework for enhancing chemodynamic therapy via redox dyshomeostasis
LL Zhou, Q Guan, WY Li, Z Zhang, YA Li, YB Dong - Small, 2021 - Wiley Online Library
Chemodynamic therapy (CDT), which induces cell death by decomposing high levels of
H2O2 in tumor cells into highly toxic· OH, is recognized as a promising antineoplastic …
H2O2 in tumor cells into highly toxic· OH, is recognized as a promising antineoplastic …
International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis
Macroautophagy/autophagy is a complex degradation process with a dual role in cell death
that is influenced by the cell types that are involved and the stressors they are exposed to …
that is influenced by the cell types that are involved and the stressors they are exposed to …
Dissecting the crosstalk between endothelial mitochondrial damage, vascular inflammation, and neurodegeneration in cerebral amyloid angiopathy and Alzheimer's …
Alzheimer's disease (AD) is the most prevalent cause of dementia and is pathologically
characterized by the presence of parenchymal senile plaques composed of amyloid β (Aβ) …
characterized by the presence of parenchymal senile plaques composed of amyloid β (Aβ) …
Organelle‐specific mechanisms in crosstalk between apoptosis and ferroptosis
P Wu, X Zhang, D Duan, L Zhao - Oxidative Medicine and …, 2023 - Wiley Online Library
Apoptosis has been extensively studied, whereas ferroptosis is a newly discovered form of
regulated cell death that involves iron‐dependent accumulations of lipid hydroperoxides …
regulated cell death that involves iron‐dependent accumulations of lipid hydroperoxides …
Oxidative stress and mitochondrial dysfunction associated with peripheral neuropathy in type 1 diabetes
E Eftekharpour, P Fernyhough - Antioxidants & Redox Signaling, 2022 - liebertpub.com
Significance: This review highlights the many intracellular processes generating reactive
oxygen species (ROS) in the peripheral nervous system in the context of type 1 diabetes …
oxygen species (ROS) in the peripheral nervous system in the context of type 1 diabetes …
GPX4 overexpressed non-small cell lung cancer cells are sensitive to RSL3-induced ferroptosis
JW Kim, DW Min, D Kim, J Kim, MJ Kim, H Lim… - Scientific Reports, 2023 - nature.com
Ferroptosis can be induced by inhibiting antioxidant enzymes GPX4 or system Xc−,
increased intracellular iron concentrations, and lipid peroxidation. Recently, it has been …
increased intracellular iron concentrations, and lipid peroxidation. Recently, it has been …