Combination antiretroviral therapy (ART) can block multiple stages of the HIV-1 life cycle to
prevent progression to AIDS in people living with HIV-1. However, owing to the persistence …

The HIV genome encodes a small number of viral proteins (ie, 16), invariably establishing
cooperative associations among HIV proteins and between HIV and host proteins, to invade …

The Fc region of HIV-1 Env-specific broadly neutralizing antibodies (bNAbs) is required for
suppressing viraemia, through mechanisms which remain poorly understood. Here, we …

The HIV-1 envelope glycoprotein (Env)(gp120-gp41) 3 is the target for neutralizing
antibodies and antibody-dependent cellular cytotoxicity (ADCC). HIV-1 Env is flexible …

Interactions between the Fc segment of IgG and its receptors (FcγRs) found on cells such as
natural killer cells, monocytes, macrophages and neutrophils can potentially mediate …

Summary While HIV-1-mediated CD4 downregulation protects infected cells from antibody-
dependent cellular cytotoxicity (ADCC), shed gp120 binds to CD4 on uninfected bystander …

The establishment and maintenance of HIV reservoirs that lead to persistent viremia in
patients on antiretroviral drugs remains the greatest challenge of the highly active …

The conformation of the HIV-1 envelope glycoprotein (Env) substantially impacts antibody
recognition and antibody-dependent cellular cytotoxicity (ADCC) responses. In the absence …

The optimization, based on computational, thermodynamic, and crystallographic data, of a
series of small-molecule ligands of the Phe43 cavity of the envelope glycoprotein gp120 of …

Cancer is a complex group of diseases with multiple eventual causes. The underlying
causes are not fully known. Thus, learning more about the known causes of cancer is an …