The increasing incidence of microbial resistance and newly emerging pathogens have
become a serious challenge for public health. More and more efforts have been directed to …

Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's
sarcoma, primary effusion lymphoma and multicentric Castleman's disease. Since the …

Emergence of drug-resistance to all FDA-approved antiherpesvirus agents is an increasing
concern in immunocompromised patients. Herpesvirus DNA polymerase (DNApol) is …

A series of semisynthetic triterpenoids with A-ring azepano-and A-seco-fragments as well as
hydrazido/hydrazono-substituents at C3 and C28 has been synthesized and evaluated for …

Kaposi's sarcoma-associated herpesvirus (KSHV) is a γ-herpesvirus closely associated with
Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman disease. Open …

Allostery is one of the most direct and efficient ways to regulate protein functions. The
diverse allosteric sites make it possible to design allosteric modulators of differential …

More than 90% of the world's population is infected with a herpesvirus. 1 Despite this
staggering fact, only a handful of approved drugs exist for the general treatment of …

Targeting of cryptic binding sites represents an attractive but underexplored approach to
modulating protein function with small molecules. Using the dimeric protease (Pr) from …

Herpesviruses encode a characteristic serine protease with a unique fold and an active site
that comprises the unusual triad Ser-His-His. The protease is essential for viral replication …

KSHV is linked to three malignancies: Kaposi sarcoma, primary effusion lymphoma, and
multicentric Castleman disease. Despite significant progress in understanding KSHV …