Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

Immune responses depend on the ability of leukocytes to move from the circulation into
tissue. This is enabled by mechanisms that guide leukocytes to the right exit sites and allow …

The infusion of coronavirus disease 2019 (COVID-19) patients with mesenchymal stem cells
(MSCs) potentially improves clinical symptoms, but the underlying mechanism remains …

Neutrophils play a critical role in the host defense against bacterial and fungal infections, but
their inappropriate activation also contributes to tissue damage during autoimmune and …

The adhesive interactions of cells with their environment through the integrin family of
transmembrane receptors have key roles in regulating multiple aspects of cellular …

Integrin receptors provide a dynamic, tightly-regulated link between the extracellular matrix
(or cellular counter-receptors) and intracellular cytoskeletal and signalling networks …

Osteopetrosis is a genetic condition of increased bone mass, which is caused by defects in
osteoclast formation and function. Both autosomal recessive and autosomal dominant forms …

Cell-directed changes in the ligand-binding affinity ('activation') of integrins regulate cell
adhesion and migration, extracellular matrix assembly and mechanotransduction, thereby …

When platelet numbers are low or when their function is disabled, the risk of bleeding is
high, which on the one hand indicates that in normal life vascular damage is a rather …

Integrins are transmembrane cell–adhesion molecules that carry signals from the outside to
the inside of the cell and vice versa. Like other cell surface receptors, integrins signal in …