Calcium signaling underlies much of physiology. Almost all the Ca2+ in the cytoplasm is
bound to buffers, with typically only∼ 1% being freely ionized at resting levels in most cells …

The various splice variants of the three SERCA-and the two SPCA-pump genes in higher
vertebrates encode P-type ATPases of the P2A group found respectively in the membranes …

Percutaneous revascularization revolutionized the therapy of patients with coronary artery
disease. Despite continuous technical advances that substantially improved patients' …

Streptococcus pneumoniae accounts for more deaths worldwide than any other single
pathogen through diverse disease manifestations including pneumonia, sepsis and …

P-type ATPases are found in all kingdoms of life and constitute a wide range of cation
transporters, primarily for H+, Na+, K+, Ca2+, and transition metal ions such as Cu (I), Zn (II) …

The Golgi apparatus plays a central role in lipid and protein post-translational modification
and sorting. Morphologically the organelle is heterogeneous and it is possible to distinguish …

Aims Our aim was to identify new microRNAs (miRNAs) implicated in pathological vascular
smooth muscle cells (VSMCs) proliferation and characterize their mechanism of action …

Vascular smooth muscle cells (VSMCs) are involved in all stages of the progression of
human atherosclerosis (AS). MicroRNAs (miRNAs or miRs) are non‑coding, small RNAs that …

Osteoclast maturation and function primarily depend on receptor activator of NF-κB ligand
(RANKL)-mediated induction of nuclear factor of activated T cells c1 (NFATc1), which is …

Constitutive vesicle trafficking is the default pathway used by all cells for movement of
intracellular cargoes between subcellular compartments and in and out of the cell …