The beta-3 adrenergic receptor (β3-AR) is by far the least studied isotype of the beta-
adrenergic sub-family. Despite its study being long hampered by the lack of suitable animal …

G-protein coupled receptors (GPCRs) transduce a wide range of extracellular signals. They
are key players in the majority of biologic functions including vision, olfaction, chemotaxis …

Numerous studies recently showed that the inhibitory neurotransmitter, γ-aminobutyric acid
(GABA), can stimulate cerebral angiogenesis and promote neurovascular coupling by …

Despite of the major role of aquaporin (AQP) water channels in controlling transmembrane
water fluxes, alternative ways for modulating water permeation have been proposed. In the …

Background: Platelets can support cancer progression via the release of microparticles and
microvesicles that enhance the migratory behaviour of recipient cancer cells. We recently …

β3‐Adrenoceptor agonists have proven useful in the treatment of overactive bladder
syndrome, but it is not known whether their efficacy during chronic administration may be …

Lysosomes are acidic Ca2+ storage organelles that actively generate local Ca2+ signaling
events to regulate a plethora of cell functions. Here, we characterized lysosomal Ca2+ …

We previously reported the novel finding that β3-AR is functionally expressed in the renal
tubule and shares its cellular localization with the vasopressin receptor AVPR2, whose …

Annually, peripheral arterial disease is estimated to cost over USD 21 billion and diabetic
foot disease an estimated at USD 9–13 billion. Mirabegron is a TGA-approved beta-3 …

Autosomal dominant polycystic kidney disease (ADPKD) disrupts renal parenchyma through
progressive expansion of fluid‐filled cysts. The only approved pharmacotherapy for ADKPD …