Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

The incidence and prevalence of hypertension is increasing worldwide, with approximately
1.13 billion of people currently affected by the disease, often in association with other …

Obesity and type 2 diabetes mellitus (T2DM) impact more than 2.5 billion adults worldwide,
necessitating innovative therapeutic approaches. Unimolecular polypharmacology, which …

Nutritional, endocrine, and neurological signals converge in multiple brain centres to control
feeding behaviour and food intake as part of the allostatic regulation of energy balance …

Objective Pharmacological strategies that engage multiple mechanisms-of-action have
demonstrated synergistic benefits for metabolic disease in preclinical models. One …

In the last thirty years, obesity has reached epidemic proportions and is now regarded as a
major health issue in contemporary society trending to serious economic and social …

Background Obesity in both adults and children is a primary health concern that can lead to
many complications at a young age, including insulin resistance, type 2 diabetes, and other …

During recent years combining GLP-1 and glucagon receptor agonism with the purpose of
achieving superior weight loss and metabolic control compared to GLP-1 alone has …

Transdermal drug delivery (TDD) has recently emerged as an effective alternative to oral
and injection administration because of its less invasiveness, low rejection rate, and …

The concerning worldwide increase of obesity and chronic metabolic diseases, such as
T2D, dyslipidemia, and cardiovascular disease, motivates further investigations into …