Mutations in methyl CpG binding protein 2 (MeCP2) are the major cause of Rett syndrome
(RTT), a rare neurodevelopmental disorder with a notable period of developmental …

Rett syndrome (RTT) is an extremely invalidating, cureless, developmental disorder, and it is
considered one of the leading causes of intellectual disability in female individuals. The vast …

ABSTRACT NPPA/atrial natriuretic peptide (natriuretic peptide type A) exerts critical
pleiotropic effects in the cardiovascular system, limiting cardiomyocyte hypertrophy and …

Heterochromatin maintains genome integrity and function, and is organised into distinct
nuclear domains. Some of these domains are proposed to form by phase separation through …

Satellite DNAs are tandemly repeated sequences organized in large clusters within (peri)
centromeric and/or subtelomeric heterochromatin. However, in many species, satellite DNAs …

Rett syndrome (RTT, online MIM 312750) is a devastating neurodevelopmental disorder
characterized by motor and cognitive disabilities. It is mainly caused by pathogenetic …

Chromatin is a vital and dynamic structure that is carefully regulated to maintain proper cell
homeostasis. A great deal of this regulation is dependent on histone proteins which have the …

Heart failure is a major side effect of doxorubicin (DOX) treatment in patients with cancer.
However, the mechanisms underlying the development of DOX-induced heart failure need …

Pervasive transcription of the mammalian genome produces hundreds of thousands of
noncoding RNAs (ncRNAs). Numerous studies have suggested that some of these ncRNAs …

Chromatin structure plays an essential role in eukaryotic gene expression and cell identity.
Traditionally, DNA and histone modifications have been the focus of chromatin regulation; …