The epidemiology of prostate cancer

CH Pernar, EM Ebot, KM Wilson… - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
Prostate cancer is a major cause of disease and mortality among men, and each year 1.6
million men are diagnosed with and 366,000 men die of prostate cancer. In this review, we …

The beneficial effects of metformin on cancer prevention and therapy: a comprehensive review of recent advances

P Saraei, I Asadi, MA Kakar… - Cancer management and …, 2019 - Taylor & Francis
Metformin is a widely used drug in today's prescriptions by physicians due to its specific
effects in treating and curing type II diabetes. Diabetes is a common disease that may occur …

[HTML][HTML] Metformin: from mechanisms of action to therapies

M Foretz, B Guigas, L Bertrand, M Pollak, B Viollet - Cell metabolism, 2014 - cell.com
Metformin is currently the first-line drug treatment for type 2 diabetes. Besides its glucose-
lowering effect, there is interest in actions of the drug of potential relevance to cardiovascular …

[HTML][HTML] Metformin as an adjuvant treatment for cancer: a systematic review and meta-analysis

C Coyle, FH Cafferty, C Vale, RE Langley - Annals of Oncology, 2016 - Elsevier
This systematic review and meta-analysis is the first to evaluate the evidence for an
association between metformin use and cancer outcomes in patients undergoing treatment …

[HTML][HTML] Metformin in cancer prevention and therapy

J Kasznicki, A Sliwinska, J Drzewoski - Annals of translational …, 2014 - ncbi.nlm.nih.gov
The prevalence of diabetes is dramatically increasing worldwide. The results of numerous
epidemiological studies indicate that diabetic population is not only at increased risk of …

Patients with ankylosing spondylitis have increased cardiovascular and cerebrovascular mortality: a population-based study

NN Haroon, JM Paterson, P Li, RD Inman… - Annals of internal …, 2015 - acpjournals.org
Background: Ankylosing spondylitis (AS) is a chronic inflammatory arthritis affecting the
spine in young adults. It is associated with excess cardiovascular and cerebrovascular …

Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response

VE Zannella, A Dal Pra, H Muaddi, TD McKee… - Clinical cancer …, 2013 - AACR
Purpose: Tumor hypoxia is a negative prognostic factor in multiple cancers, due in part to its
role in causing resistance to radiotherapy. Hypoxia arises in tumor regions distal to blood …

Prostate cancer progression and mortality: a review of diet and lifestyle factors

SF Peisch, EL Van Blarigan, JM Chan… - World journal of …, 2017 - Springer
Purpose To review and summarize evidence on the role of diet and lifestyle factors and
prostate cancer progression, with a specific focus on habits after diagnosis and the risk of …

Cancer, obesity, diabetes, and antidiabetic drugs: is the fog clearing?

AJ Klil-Drori, L Azoulay, MN Pollak - Nature reviews Clinical oncology, 2017 - nature.com
The prevalence of obesity, of type 2 diabetes mellitus (T2DM), and of cancer are all
increasing globally. The relationships between these diseases are complex, and thus …

[HTML][HTML] Type 2 diabetes mellitus and cancer: the role of pharmacotherapy

G Shlomai, B Neel, D LeRoith… - Journal of Clinical …, 2016 - ncbi.nlm.nih.gov
Purpose Type 2 diabetes mellitus (T2DM) is becoming increasingly prevalent worldwide.
Epidemiologic data suggest that T2DM is associated with an increased incidence and …