Abstract Apixaban (BMS-562247; 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)
phenyl)-4, 5, 6, 7-tetrahydro-1 H-pyrazolo [3, 4-c] pyridine-3-carboxamide), a direct inhibitor …

Given the important agricultural and medicinal application of optically pure heterocycles
bearing a trifluoromethyl group at the stereogenic carbon center in the heterocyclic …

Factor Xa (fXa) plays a critical role in the coagulation cascade, serving as the point of
convergence of the intrinsic and extrinsic pathways. Together with nonenzymatic cofactor Va …

Modification of a series of pyrazole factor Xa inhibitors to incorporate an
aminobenzisoxazole as the P1 ligand resulted in compounds with improved selectivity for …

Cuts both ways: The title reaction consists of an addition/cyclization/dehydration sequence
and affords the biologically important chiral 3, 5‐diaryl‐5‐(trifluoromethyl)‐2‐isoxazolines 1 …

Isoxazoline is a 5-membered heterocycle present in the active compounds of many
commercial veterinary anti-ectoparasitic products. The molecular target of isoxazolines is the …

Arterial and venous thrombosis are major causes of morbidity and mortality. Arterial
thrombosis is the most common cause of myocardial infarction, stroke, and limb gangrene …

Hereditary angioedema (HAE) is a rare and potentially life-threatening disease that affects
an estimated 1 in 50 000 individuals worldwide. Until recently, prophylactic HAE treatment …

Cardiovascular and cerebrovascular diseases continue to be the leading cause of death
throughout the world. Over the past two decades, great advances have been made in the …

A series of 138 nonchiral 3-amidinobenzyl-1 H-indole-2-carboxamides and analogues as
inhibitors of the blood coagulation enzyme factor Xa (fXa) were designed, synthesized, and …