Gold nanoparticles are emerging as promising nanomaterials to create nanoscale
therapeutic delivery systems. The aim of the study was to synthesis of highly monodisperse …

Neurons require physiological IFN-γ signaling to maintain central nervous system (CNS)
homeostasis, however, pathological IFN-γ signaling can cause CNS pathologies. The …

Abstract Spinal Muscular Atrophy (SMA) is a severe genetic neuromuscular disorder that
occurs in childhood and is caused by misexpression of the survival motor neuron (SMN) …

Huntington's disease (HD) is a chronic neurodegenerative disorder characterized by a late
clinical onset despite ubiquitous expression of the mutant Huntingtin gene (HTT) from birth …

Spinal muscular atrophy (SMA), a recessive neurodegenerative disease, is characterized by
the selective loss of spinal motor neurons. No available therapy exists for SMA, which …

Objectives Spinal Muscular Atrophy (SMA) presents challenges in (i) monitoring disease
activity and predicting progression,(ii) designing trials that allow rapid assessment of …

Despite tremendous progress in understanding the pathobiology of astrocytoma, major gaps
remain in our knowledge of the molecular basis underlying the aggressiveness of high …

Rab7 belongs to the Ras superfamily of small GTPases and is a master regulator of early to
late endocytic membrane transport. Four missense mutations in the late endosomal Rab7 …

In the last decade, nerve tissue engineering has attracted much attention due to the
incapability of self-regeneration. Nerve tissue regeneration is mainly based on scaffold …

Background Abuse of heroin and prescription opiate medications has grown to disturbing
levels. Opioids mediate their effects through mu opioid receptors (MOR), but minimal …