Cancer-derived exosomes: their role in cancer biology and biomarker development

VC Kok, CC Yu - International Journal of Nanomedicine, 2020 - Taylor & Francis
Exosomes are a subset of tiny extracellular vesicles manufactured by all cells and are
present in all body fluids. They are produced actively in tumor cells, which are released and …

Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression

E Yang, X Wang, Z Gong, M Yu, H Wu… - Signal transduction and …, 2020 - nature.com
Metabolic reprogramming is reported to be one of the hallmarks of cancer, which is an
adaptive mechanism by which fast-growing cancer cells adapt to their increasing energy …

Extracellular vesicles remodel tumor environment for cancer immunotherapy

M Yue, S Hu, H Sun, B Tuo, B Jia, C Chen, W Wang… - Molecular Cancer, 2023 - Springer
Tumor immunotherapy has transformed neoplastic disease management, yet low response
rates and immune complications persist as major challenges. Extracellular vesicles …

Exosomes as new generation vehicles for drug delivery: biomedical applications and future perspectives

A Rajput, A Varshney, R Bajaj, V Pokharkar - Molecules, 2022 - mdpi.com
Currently, particular interest among the scientific community is focused on exploring the use
of exosomes for several pharmaceutical and biomedical applications. This is due to the …

Exosomes as drug delivery systems: A brief overview and progress update

SM Patil, SS Sawant, NK Kunda - European Journal of Pharmaceutics and …, 2020 - Elsevier
Exosomes are intracellular membrane-based vesicles with diverse compositions that are
involved in biological and pathological processes. Since the discovery of exosomes, they …

CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA

A Conigliaro, V Costa, A Lo Dico, L Saieva, S Buccheri… - Molecular cancer, 2015 - Springer
Background CD90+ liver cancer cells have been described as cancer stem-cell-like (CSC),
displaying aggressive and metastatic phenotype. Using two different in vitro models, already …

Extracellular vesicles: emerging targets for cancer therapy

P Vader, XO Breakefield, MJA Wood - Trends in molecular medicine, 2014 - cell.com
Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are
released by almost all cell types, including tumour cells. Through transfer of their molecular …

Intercellular communication by exosome-derived microRNAs in cancer

BN Hannafon, WQ Ding - International journal of molecular sciences, 2013 - mdpi.com
The development of human cancers is a multistep process in which normal cells acquire
characteristics that ultimately lead to their conversion into cancer cells. Many obstacles must …

Exosome as a delivery vehicle for cancer therapy

B Moon, S Chang - Cells, 2022 - mdpi.com
Exosomes are small extracellular vesicles that are naturally produced and carry
biomolecules such as proteins, microRNAs, and metabolites. Because of their small size …

[HTML][HTML] Exosomal proteins as diagnostic biomarkers in lung cancer

B Sandfeld-Paulsen, KR Jakobsen, R Bæk… - Journal of Thoracic …, 2016 - Elsevier
Introduction Exosomes have been suggested as promising biomarkers in NSCLC because
they contain proteins from their originating cells and are readily available in plasma. In this …