Optimization of mesenchymal stromal cell (MSC) manufacturing processes for a better therapeutic outcome

ME Fernández-Santos, M Garcia-Arranz… - Frontiers in …, 2022 - frontiersin.org
MSCs products as well as their derived extracellular vesicles, are currently being explored
as advanced biologics in cell-based therapies with high expectations for their clinical use in …

[HTML][HTML] Mesenchymal stromal cell secretome for traumatic brain injury: Focus on immunomodulatory action

F Pischiutta, E Caruso, H Cavaleiro, AJ Salgado… - Experimental …, 2022 - Elsevier
The severity and long-term consequences of brain damage in traumatic brain injured (TBI)
patients urgently calls for better neuroprotective/neuroreparative strategies for this …

AIF1+ CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

C Zong, Y Meng, F Ye, X Yang, R Li, J Jiang, Q Zhao… - Hepatology, 2023 - journals.lww.com
AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an infla... : Hepatology AIF1+CSF1R+
MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote …

Skin-Derived ABCB5+ Mesenchymal Stem Cells for High-Medical-Need Inflammatory Diseases: From Discovery to Entering Clinical Routine

E Niebergall-Roth, NY Frank, C Ganss… - International Journal of …, 2022 - mdpi.com
The ATP-binding cassette superfamily member ABCB5 identifies a subset of skin-resident
mesenchymal stem cells (MSCs) that exhibit potent immunomodulatory and wound healing …

Mesenchymal stem/stromal cells: immunomodulatory and bone regeneration potential after tumor excision in osteosarcoma patients

M Baron, P Drohat, B Crawford, FJ Hornicek, TM Best… - Bioengineering, 2023 - mdpi.com
Osteosarcoma (OS) is a type of bone cancer that is derived from primitive mesenchymal
cells typically affecting children and young adults. The current standard of treatment is a …

Recent advances in extracellular vesicle-based therapies using induced pluripotent stem cell-derived mesenchymal stromal cells

GM Bertolino, M Maumus, C Jorgensen, D Noël - Biomedicines, 2022 - mdpi.com
Extracellular vesicles (EVs) are being widely investigated as acellular therapeutics in
regenerative medicine applications. EVs isolated from mesenchymal stromal cells (MSCs) …

[HTML][HTML] Banking of perinatal mesenchymal stem/stromal cells for stem cell-based personalized medicine over lifetime: Matters arising

CH Li, J Zhao, HY Zhang, B Wang - World Journal of Stem Cells, 2023 - ncbi.nlm.nih.gov
Mesenchymal stromal/stem cells (MSCs) are currently applied in regenerative medicine and
tissue engineering. Numerous clinical studies have indicated that MSCs from different tissue …

Systematic review and meta-analysis of randomized controlled trials of mesenchymal stromal cells to treat coronavirus disease 2019: is it too late?

AM Kirkham, AJM Bailey, R Shorr, MM Lalu… - Cytotherapy, 2023 - Elsevier
Background aims Evidence regarding the extent that mesenchymal stromal cells (MSCs)
may improve clinical outcomes in patients with coronavirus disease 2019 (COVID-19) has …

Bone marrow-derived mesenchymal stem cells reduce CCl4-induced kidney injury and fibrosis in male Wistar rats

A Adel, M Abdul-Hamid, SH Abdel-Kawi… - Renal …, 2024 - Taylor & Francis
Aim This study explores the possible therapeutic role of rats and mice bone marrow-derived
mesenchymal stem cells (BM-MSCs) on renal damage and toxicity brought on by carbon …

Managing the heterogeneity of mesenchymal stem cells for cartilage regenerative therapy: A review

D Goh, Y Yang, EH Lee, JHP Hui, Z Yang - Bioengineering, 2023 - mdpi.com
Articular cartilage defects commonly result from trauma and are associated with significant
morbidity. Since cartilage is an avascular, aneural, and alymphatic tissue with a poor …