Female eutherians transcriptionally silence one X chromosome to balance gene dosage
between the sexes. X-chromosome inactivation (XCI) is initiated by the lncRNA Xist, which …

Sexual dimorphism has been reported in various human diseases including autoimmune
diseases, neurological diseases, pulmonary arterial hypertension, and some types of …

Human in vitro oogenesis provides a framework for clarifying the mechanism of human
oogenesis. To create its benchmark, it is vital to promote in vitro oogenesis using a model …

X-chromosome inactivation is a paradigm of epigenetic transcriptional regulation. Female
human embryonic stem cells (hESCs) often undergo erosion of X-inactivation upon …

Human pluripotent stem cells (hPSCs) are a powerful tool for disease modeling of hard-to-
access tissues (such as the brain). Current protocols either direct neuronal differentiation …

Human pluripotent stem cells (hPSCs) regularly and irreversibly show the erosion of X
chromosome inactivation (XCI) by long non-coding RNA (lncRNA) XIST silencing, causing …

Abstract DNMT3A/B and TET1 play indispensable roles in regulating DNA methylation that
undergoes extensive reprogramming during mammalian embryogenesis. Yet the …

High-resolution imaging analysis using various types of cells is an essential tool for
dissecting cell functions. Generally, obtaining such images requires the cells to be cultured …

The mutation of X-linked protocadherin (PCDH) 19 gene in heterozygous females causes
epilepsy. However, because of the erosion of X-chromosome inactivation (XCI) in female …

Epigenetic variation in the X chromosome inactivation (XCI) of human induced pluripotent
stem cells (hiPSCs) can impact their ability to accurately model biological sex biases …