[HTML][HTML] Telomere length as a marker of biological age: state-of-the-art, open issues, and future perspectives

A Vaiserman, D Krasnienkov - Frontiers in Genetics, 2021 - frontiersin.org
Telomere shortening is a well-known hallmark of both cellular senescence and organismal
aging. An accelerated rate of telomere attrition is also a common feature of age-related …

Cancer and aging: two tightly interconnected biological processes

L Berben, G Floris, H Wildiers, S Hatse - Cancers, 2021 - mdpi.com
Simple Summary As life expectancy is increasing, the older population is rapidly growing.
However, older patients with cancer are still underrepresented in clinical trials, making …

Determinants of telomere length across human tissues

K Demanelis, F Jasmine, LS Chen, M Chernoff, L Tong… - Science, 2020 - science.org
INTRODUCTION Telomeres are DNA-protein complexes located at the end of chromosomes
that protect chromosome ends from degradation and fusion. The DNA component of …

[HTML][HTML] Telomere length and all-cause mortality: a meta-analysis

Q Wang, Y Zhan, NL Pedersen, F Fang, S Hägg - Ageing research reviews, 2018 - Elsevier
Telomere attrition is associated with increased morbidity and mortality of various age-related
diseases. Reports of association between telomere length (TL) and all-cause mortality …

[HTML][HTML] Towards an understanding of the physical activity-BDNF-cognition triumvirate: A review of associations and dosage

EI Walsh, L Smith, J Northey, B Rattray… - Ageing research …, 2020 - Elsevier
Physical activity has received substantial research attention due to its beneficial impact on
cognition in ageing, particularly via the action of brain-derived neurotrophic factor (BDNF). It …

The fetal programming of telomere biology hypothesis: an update

S Entringer, K de Punder, C Buss… - … Transactions of the …, 2018 - royalsocietypublishing.org
Research on mechanisms underlying fetal programming of health and disease risk has
focused primarily on processes that are specific to cell types, organs or phenotypes of …

Telomere biology and age-related diseases

M Herrmann, I Pusceddu, W März… - Clinical Chemistry and …, 2018 - degruyter.com
Telomeres are the protective end caps of chromosomes and shorten with every cell division.
Telomere length has been proposed as a biomarker of biological age and a risk factor for …

A healthy lifestyle is positively associated with mental health and well-being and core markers in ageing

P Hautekiet, ND Saenen, DS Martens, M Debay… - BMC medicine, 2022 - Springer
Background Studies often evaluate mental health and well-being in association with
individual health behaviours although evaluating multiple health behaviours that co-occur in …

Telomere length measurement as a clinical biomarker of aging and disease

CL Fasching - Critical reviews in clinical laboratory sciences, 2018 - Taylor & Francis
Telomere length measurement is increasingly recognized as a clinical gauge for age-related
disease risk. There are several methods for studying blood telomere length (BTL) as a …

An integrative study of five biological clocks in somatic and mental health

R Jansen, LKM Han, JE Verhoeven, KA Aberg… - Elife, 2021 - elifesciences.org
Biological clocks have been developed at different molecular levels and were found to be
more advanced in the presence of somatic illness and mental disorders. However, it is …