Mevalonate pathway is an important metabolic pathway which plays a key role in multiple
cellular processes by synthesizing sterol isoprenoids, such as cholesterol, and non-sterol …

ContextKnee osteoarthritis (OA) is a leading cause of disability in older persons. Few risk
factors for disease progression or functional decline have been identified. Hip-knee-ankle …

ContextProton pump inhibitors (PPIs) may interfere with calcium absorption through
induction of hypochlorhydria but they also may reduce bone resorption through inhibition of …

Purpose Recent observational studies suggest that various drugs are remarkably effective at
reducing morbidity and mortality. These cohort studies used a flawed approach to design …

Our meta-analysis assessed the efficacy of statins on the risk of fracture, bone mineral
density (BMD), and the markers of bone metabolism by collecting data from 33 clinical trials …

Background & Aims: Endogenous hyperinsulinemia in the context of type 2 diabetes mellitus
is potentially associated with an increased risk of colorectal cancer. We aimed to determine …

Background Efficacy of statins has been extensively studied, with much less information
reported on their unintended effects. Evidence from randomized controlled trials (RCTs) on …

There is accumulating evidence that statins have beneficial effects that are independent of
their classical actions on lipoproteins. These effects include reductions in inflammation in the …

OBJECTIVE: To estimate the lifetime risk of undergoing primary total hip (THR) or knee
(TKR) replacement in the UK. METHOD: A Population-based cohort study of 25,845 patients …

Objectives To assess the completeness and representativeness of body mass index (BMI)
data in the Clinical Practice Research Datalink (CPRD), and determine an optimal strategy …