Inflammatory molecules play a crucial role in the pathogenesis of inflammatory bowel
disease (IBD) such as ulcerative colitis and Crohn's disease, both of which are chronic …

The incidence of inflammatory bowel diseases (IBD) worldwide has resulted in a global
public health challenge. Intestinal fibrosis leading to stricture formation and bowel …

Inflammatory bowel disease (IBD) is a group of chronic inflammatory conditions of the
gastrointestinal tract that includes two major phenotypes, Crohn's disease and ulcerative …

Ulcerative Colitis (UC) has been reported to be related to Porphyromonas gingivalis (P.
gingivalis). Porphyromonas gingivalis peptidylarginine deiminase (PPAD), a virulence factor …

TL1A and its functional receptor DR3 are members of the TNF/TNFR superfamilies of
proteins. Binding of APC-derived TL1A to lymphocytic DR3 provides co-stimulatory signals …

Background Intestinal fibrosis resulting in stricture formation and obstruction in Crohn's
disease (CD) and increased wall stiffness leading to symptoms in ulcerative colitis (UC) is …

Crohn's disease is an idiopathic disorder of the gut thought to be caused by a combination of
environmental and genetic factors in susceptible individuals. It is characterized by chronic …

Proinflammatory cytokines are thought to modulate pathogeneses of various inflammatory
bowel diseases (IBDs). Thymic stromal lymphopoietin (TSLP), which has been studied in …

Purpose Previous studies revealed an association of tumor necrosis factor super family-15
(TNFSF15) gene polymorphisms with several autoimmune diseases, but their roles in the …

Aims Human genetic, tissue expression, proteomics, transcriptomics and nonclinical studies
implicate tumour necrosis factor α‐like ligand 1A (TL1A) as a novel target in inflammatory …