TP53 is the most commonly mutated gene in human cancer with over 100,000 literature
citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a …

Altered gene expression is the primary molecular mechanism responsible for the
pathological processes of human diseases, including cancer. MicroRNAs (miRNAs) are …

Akt is a serine/threonine kinase and it participates in the key role of the PI3K signaling
pathway. The Akt can be activated by a wide range of growth signals and the biochemical …

Head and neck cancers (HNCs) are a group of heterogeneous tumors formed most
frequently from epithelial cells of the larynx, lips, oropharynx, nasopharynx, and mouth …

MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …

A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can
be sensed by specific sensors, then trigger a series of signal transduction pathways and …

With the advent of next generation sequencing techniques a previously unknown world of
non-coding RNA molecules have been discovered. Non-coding RNA transcripts likely …

Accumulating evidence indicates that circular RNAs (circRNAs) are abundant in the human
transcriptome. However, their involvement in biological processes, including pluripotency …

Importance Biomarkers for the early diagnosis of patients with pancreatic cancer are needed
to improve prognosis. Objectives To describe differences in microRNA expression in whole …

The p53 tumor suppressor is a key transcription factor regulating cellular pathways such as
DNA repair, cell cycle, apoptosis, angiogenesis, and senescence. It acts as an important …