Unravelling the molecular mechanisms underlying gastric carcinogenesis is one of the
major challenges in cancer genomics. Gastric cancer is a very complex and heterogeneous …

MUTYH is a base excision repair enzyme, it plays a crucial role in the correction of DNA
errors from guanine oxidation and may be considered a cell protective factor. In humans it is …

MUTYH, a human ortholog of MutY, is a post-replicative DNA glycosylase, highly conserved
throughout evolution, involved in the correction of mismatches resulting from a faulty …

Background Lung adenocarcinoma (LUAD) is the most prevalent subtype of lung cancer,
and comprehending its molecular mechanisms is pivotal for advancing treatment efficacy …

The effects of abnormalities in the DNA glycosylases NEIL1, NEIL2, and NEIL3 on human
cancer have not been fully elucidated. In this paper, we found that the median somatic total …

DNA adducts are a major cause of DNA mutation and DNA mutation-related diseases, but
the simultaneous identification of multiple DNA adducts has been a challenge for a decade …

Abstract Polo-like kinase 4 (PLK4) is a centrosomal protein that is involved in the regulation
of centrosome duplication. This study aimed to determine whether the genetic abnormality of …

R-spondin (RSPO) gene fusions have recently been discovered in a subset of human
colorectal cancer (CRC) in the US population; however, whether the fusion is recurrent in …

Recent progress in targeted therapy for lung cancer has revealed that accurate differential
diagnosis between squamous cell carcinoma (SCC) and adenocarcinoma (ADC) of the lung …

The human DNA base excision repair enzyme MUTYH (MutY homolog DNA glycosylase)
excises undamaged adenine that has been misincorporated opposite the oxidatively …