Lipid second messengers have essential roles in cellular function and contribute to the
molecular mechanisms that underlie inflammation, malignant transformation, invasiveness …

Interaction of extracellular-signal molecules with cell-surface receptors often activates a
phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine and other …

The bioactive phospholipids, lysophosphatidic acid (LPA) and phosphatidic acid (PA),
regulate pivotal processes related to the pathogenesis of cancer. Here, we report …

Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for
G protein-coupled receptors. While LPA exerts effects throughout the body in normal …

Phospholipase D (PLD) is a phosphatidyl choline (PC)-hydrolyzing enzyme that generates
phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular …

Lysophosphatidic acid (LPA, 1‐radyl‐2‐hydroxy‐sn‐glycero‐3‐phosphate) is the prototype
member of a family of lipid mediators and second messengers. LPA and its naturally …

A series of 4-substituted methoxybenzoyl-aryl-thiazoles (SMART) have been discovered and
synthesized as a result of structural modifications of the lead compound 2-arylthiazolidine-4 …

Two G protein-coupled receptors (Edg-2) and (Edg-4) for the lysolipid phosphoric acid
mediator lysophosphatidic acid have been described by molecular cloning. However, the …

Ascitic fluid and plasma from ovarian cancer patients, but not from patients with
nongynecological tumors, contain elevated levels of the bioactive phospholipid …

To improve the selectivity and antiproliferative activity of previously reported serine amide
phosphates (SAPs), we designed a new series of 4-thiazolidinone amides, in which the 4 …