Diet as a whole, encompassing food composition, calorie intake, and the length and
frequency of fasting periods, affects the time span in which health and functional capacity …

Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

The geroscience hypothesis proposes that therapy to slow or reverse molecular changes
that occur with aging can delay or prevent multiple chronic diseases and extend healthy …

Reprogrammed metabolism is a hallmark of colorectal cancer (CRC). CRC cells are geared
toward rapid proliferation, requiring nutrients and the removal of cellular waste in nutrient …

Age‐associated diseases are rising to pandemic proportions, exposing the need for efficient
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …

Aging involves the systemic deterioration of all known cell types in most eukaryotes. Several
recently discovered compounds that extend the healthspan and lifespan of model organisms …

Mammals differ more than 100-fold in maximum lifespan. Here, we conducted comparative
transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with …

Emerging new evidence highlights the importance of prolonged daily fasting periods for the
health and survival benefits of calorie restriction (CR) and time-restricted feeding (TRF) in …

Over the last decade, studies suggested that dietary behavior modification, including fasting,
can improve metabolic and cardiovascular markers as well as body composition. Given the …

Overnutrition is a risk factor for various human diseases, including neurodegenerative
diseases, metabolic disorders, and cancers. Therefore, targeting overnutrition represents a …