[HTML][HTML] Targeting iron metabolism in cancer therapy
Iron is a critical component of many cellular functions including DNA replication and repair,
and it is essential for cell vitality. As an essential element, iron is critical for maintaining …
and it is essential for cell vitality. As an essential element, iron is critical for maintaining …
The role of iron in cancer progression
Q Guo, L Li, S Hou, Z Yuan, C Li, W Zhang… - Frontiers in …, 2021 - frontiersin.org
Iron is an essential trace element for the human body, and its deficiency or excess can
induce a variety of biological processes. Plenty of evidences have shown that iron …
induce a variety of biological processes. Plenty of evidences have shown that iron …
[HTML][HTML] Protective effect of fucoidan against iron overload and ferroptosis-induced liver injury in rats exposed to alcohol
M Xue, Y Tian, Y Sui, H Zhao, H Gao, H Liang… - Biomedicine & …, 2022 - Elsevier
This study was aimed to explore the effects of fucoidan on iron overload and ferroptosis-
induced liver injury, and the underlying mechanisms in rats exposed to alcohol. Sprague …
induced liver injury, and the underlying mechanisms in rats exposed to alcohol. Sprague …
Aging is associated with increased brain iron through cortex-derived hepcidin expression
Iron is an essential molecule for biological processes, but its accumulation can lead to
oxidative stress and cellular death. Due to its oxidative effects, iron accumulation is …
oxidative stress and cellular death. Due to its oxidative effects, iron accumulation is …
Transferrin receptor‐mediated iron uptake promotes colon tumorigenesis
Transferrin receptor (TFRC) is the major mediator for iron entry into a cell. Under excessive
iron conditions, TFRC is expected to be reduced to lower iron uptake and toxicity. However …
iron conditions, TFRC is expected to be reduced to lower iron uptake and toxicity. However …
USP11-mediated LSH deubiquitination inhibits ferroptosis in colorectal cancer through epigenetic activation of CYP24A1
J Duan, D Huang, C Liu, Y Lv, L Zhang, F Chang… - Cell Death & …, 2023 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death characterized by lipid
peroxidation. Colorectal cancer (CRC) cells evade ferroptosis despite their requirement of …
peroxidation. Colorectal cancer (CRC) cells evade ferroptosis despite their requirement of …
Hypoxia-Induced Signaling in Gut and Liver Pathobiology
Oxygen (O2) is essential for cellular metabolism and biochemical reactions. When the
demand for O2 exceeds the supply, hypoxia occurs. Hypoxia-inducible factors (HIFs) are …
demand for O2 exceeds the supply, hypoxia occurs. Hypoxia-inducible factors (HIFs) are …
Iron drives anabolic metabolism through active histone demethylation and mTORC1
All eukaryotic cells require a minimal iron threshold to sustain anabolic metabolism.
However, the mechanisms by which cells sense iron to regulate anabolic processes are …
However, the mechanisms by which cells sense iron to regulate anabolic processes are …
A Bimetallic Polymerization Network for Effective Increase in Labile Iron Pool and Robust Activation of cGAS/STING Induces Ferroptosis‐Based Tumor Immunotherapy
Z Wang, P Zhou, Y Li, D Zhang, F Chu, F Yuan, B Pan… - Small, 2024 - Wiley Online Library
Due to the inherent low immunogenicity and immunosuppressive tumor microenvironment
(TME) of malignant cancers, the clinical efficacy and application of tumor immunotherapy …
(TME) of malignant cancers, the clinical efficacy and application of tumor immunotherapy …
Hypoxia-inducible factor 3α1 increases epithelial-to-mesenchymal transition and iron uptake to drive colorectal cancer liver metastasis
Background/objectives Hypoxia-inducible factor (HIF)-3α1's role in colorectal cancer (CRC)
cells, especially its effects on epithelial-mesenchymal transition (EMT), zinc finger E-box …
cells, especially its effects on epithelial-mesenchymal transition (EMT), zinc finger E-box …