[HTML][HTML] Squishy matters–Corneal mechanobiology in health and disease

SM Thomasy, BC Leonard, MA Greiner… - Progress in retinal and …, 2024 - Elsevier
The cornea, as a dynamic and responsive tissue, constantly interacts with mechanical forces
in order to maintain its structural integrity, barrier function, transparency and refractive …

Rho kinase (ROCK) inhibitors in the management of corneal endothelial disease

ZA Syed, CJ Rapuano - Current Opinion in Ophthalmology, 2021 - journals.lww.com
ROCK inhibitors are revolutionizing the subspecialty of cornea, and further research is
needed to compare long-term outcomes of ROCK inhibitor therapy to those of conventional …

Pilot study of corneal clearance with the use of a rho-kinase inhibitor after descemetorhexis without endothelial keratoplasty for Fuchs endothelial corneal dystrophy

E Davies, U Jurkunas, II Roberto Pineda - Cornea, 2021 - journals.lww.com
Purpose: To investigate corneal clearance time using a topical rho-kinase inhibitor,
netarsudil, after descemetorhexis without endothelial keratoplasty (DWEK). Methods: Twenty …

[HTML][HTML] Corneal endothelial wound healing: understanding the regenerative capacity of the innermost layer of the cornea

H Vercammen, A Miron, S Oellerich, GRJ Melles… - Translational …, 2022 - Elsevier
Currently, there are very few well-established treatments to stimulate corneal endothelial cell
regeneration in vivo as a cure for corneal endothelial dysfunctions. The most frequently …

ROCK inhibitors in ophthalmology: a critical review of the existing clinical evidence

R Karri, EW Chong - Clinical & Experimental Ophthalmology, 2023 - Wiley Online Library
Rho kinase (ROCK) inhibitors have emerged as a key therapeutic class of interest in
ophthalmology over the last decade. Promising in vitro studies laid the foundations for the …

Transient reticular cystic corneal epithelial edema with topical netarsudil: a case series and review

SA LoBue, GA Moustafa, A Vu, M Amin, T Nguyen… - Cornea, 2021 - journals.lww.com
Purpose: To describe cases in which netarsudil ophthalmic solution 0.02% precipitated
reversible, reticular cystic epithelial edema. Methods: A retrospective case review at the …

Potential functional restoration of corneal endothelial cells in Fuchs endothelial corneal dystrophy by ROCK inhibitor (Ripasudil)

U Schlötzer-Schrehardt, M Zenkel, M Strunz… - American Journal of …, 2021 - Elsevier
Purpose Rho-associated kinase (ROCK) inhibitors have been successfully used as a rescue
strategy in eyes that failed to clear after descemetorhexis without endothelial graft for …

[HTML][HTML] Netarsudil-associated reticular corneal epithelial edema

JA Tran, UV Jurkunas, J Yin, EC Davies… - American Journal of …, 2022 - Elsevier
Purpose To describe 8 cases of reversible reticular corneal epithelial edema of the cornea
that developed after use of the topical Rho-kinase inhibitor netarsudil. Methods This is a …

The soil and the seed: The relationship between Descemet's membrane and the corneal endothelium

RB Petrela, SP Patel - Experimental eye research, 2023 - Elsevier
Abstract Descemet's membrane (DM), the basement membrane of the corneal endothelium,
is formed from the extracellular matrix (ECM) secreted by corneal endothelial cells. The ECM …

ROCK inhibitors in corneal diseases and Glaucoma—a comprehensive review of these emerging drugs

L Pagano, JW Lee, M Posarelli, G Giannaccare… - Journal of Clinical …, 2023 - mdpi.com
Rho kinase (ROCK) inhibitors have gained significant attention as emerging novel treatment
options in the field of ophthalmology in recent years. The evidence supporting their efficacy …