ATR-FTIR spectroscopy and spectroscopic imaging for the analysis of biopharmaceuticals
Abstract Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) spectroscopy is
a label-free, non-destructive technique that can be applied to a vast range of biological …
a label-free, non-destructive technique that can be applied to a vast range of biological …
[HTML][HTML] Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines
Y Guo, H Bera, C Shi, L Zhang, D Cun… - Acta Pharmaceutica Sinica …, 2021 - Elsevier
Pulmonary administration route has been extensively exploited for the treatment of local
lung diseases such as asthma, chronic obstructive pulmonary diseases and respiratory …
lung diseases such as asthma, chronic obstructive pulmonary diseases and respiratory …
Assay format diversity in pre-clinical immunogenicity risk assessment: Toward a possible harmonization of antigenicity assays
A Ducret, C Ackaert, J Bessa, C Bunce, T Hickling… - MAbs, 2022 - Taylor & Francis
ABSTRACT A major impediment to successful use of therapeutic protein drugs is their ability
to induce anti-drug antibodies (ADA) that can alter treatment efficacy and safety in a …
to induce anti-drug antibodies (ADA) that can alter treatment efficacy and safety in a …
Toward drug-like multispecific antibodies by design
MS Sawant, CN Streu, L Wu, PM Tessier - International journal of …, 2020 - mdpi.com
The success of antibody therapeutics is strongly influenced by their multifunctional nature
that couples antigen recognition mediated by their variable regions with effector functions …
that couples antigen recognition mediated by their variable regions with effector functions …
AggBERT: Best in Class Prediction of Hexapeptide Amyloidogenesis with a Semi-Supervised ProtBERT Model
The prediction of peptide amyloidogenesis is a challenging problem in the field of protein
folding. Large language models, such as the ProtBERT model, have recently emerged as …
folding. Large language models, such as the ProtBERT model, have recently emerged as …
Peptide inhibitors of insulin fibrillation: Current and future challenges
B Rosetti, S Marchesan - International Journal of Molecular Sciences, 2023 - mdpi.com
Amyloidoses include a large variety of local and systemic diseases that share the common
feature of protein unfolding or refolding into amyloid fibrils. The most studied amyloids are …
feature of protein unfolding or refolding into amyloid fibrils. The most studied amyloids are …
Localized delivery of immunotherapeutics: a rising trend in the field
J Wang, Y Zhang, J Pi, D Xing, C Wang - Journal of Controlled Release, 2021 - Elsevier
Immunotherapy is becoming a new standard of care for multiple cancers, while several
limitations are impending its further clinical success. Immunotherapeutic agents often have …
limitations are impending its further clinical success. Immunotherapeutic agents often have …
Tyrosinase inhibitory peptides: structure-activity relationship study on peptide chemical properties, terminal preferences and intracellular regulation of melanogenesis …
Background Bioactive peptides have gained attention as potential alternatives to chemical-
based skin lightening agents. Based on literature search, the reported articles focused …
based skin lightening agents. Based on literature search, the reported articles focused …
Cancer Diagnostics and early detection using Electrochemical Aptasensors
The detection of early-stage cancer offers patients the best chance of treatment and could
help reduce cancer mortality rates. However, cancer cells or biomarkers are present in …
help reduce cancer mortality rates. However, cancer cells or biomarkers are present in …
In Silico identification of angiotensin-converting enzyme inhibitory peptides from MRJP1
RA Tahir, A Bashir, MN Yousaf, A Ahmed, Y Dali… - PloS one, 2020 - journals.plos.org
Hypertension is considered as one of the most common diseases that affect human beings
(both male and female) due to its high prevalence and also extending widely to both …
(both male and female) due to its high prevalence and also extending widely to both …