ATR-FTIR spectroscopy and spectroscopic imaging for the analysis of biopharmaceuticals

H Tiernan, B Byrne, SG Kazarian - … Acta Part A: Molecular and Biomolecular …, 2020 - Elsevier
Abstract Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) spectroscopy is
a label-free, non-destructive technique that can be applied to a vast range of biological …

[HTML][HTML] Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines

Y Guo, H Bera, C Shi, L Zhang, D Cun… - Acta Pharmaceutica Sinica …, 2021 - Elsevier
Pulmonary administration route has been extensively exploited for the treatment of local
lung diseases such as asthma, chronic obstructive pulmonary diseases and respiratory …

Assay format diversity in pre-clinical immunogenicity risk assessment: Toward a possible harmonization of antigenicity assays

A Ducret, C Ackaert, J Bessa, C Bunce, T Hickling… - MAbs, 2022 - Taylor & Francis
ABSTRACT A major impediment to successful use of therapeutic protein drugs is their ability
to induce anti-drug antibodies (ADA) that can alter treatment efficacy and safety in a …

Toward drug-like multispecific antibodies by design

MS Sawant, CN Streu, L Wu, PM Tessier - International journal of …, 2020 - mdpi.com
The success of antibody therapeutics is strongly influenced by their multifunctional nature
that couples antigen recognition mediated by their variable regions with effector functions …

AggBERT: Best in Class Prediction of Hexapeptide Amyloidogenesis with a Semi-Supervised ProtBERT Model

R Perez, X Li, S Giannakoulias… - Journal of Chemical …, 2023 - ACS Publications
The prediction of peptide amyloidogenesis is a challenging problem in the field of protein
folding. Large language models, such as the ProtBERT model, have recently emerged as …

Peptide inhibitors of insulin fibrillation: Current and future challenges

B Rosetti, S Marchesan - International Journal of Molecular Sciences, 2023 - mdpi.com
Amyloidoses include a large variety of local and systemic diseases that share the common
feature of protein unfolding or refolding into amyloid fibrils. The most studied amyloids are …

Localized delivery of immunotherapeutics: a rising trend in the field

J Wang, Y Zhang, J Pi, D Xing, C Wang - Journal of Controlled Release, 2021 - Elsevier
Immunotherapy is becoming a new standard of care for multiple cancers, while several
limitations are impending its further clinical success. Immunotherapeutic agents often have …

Tyrosinase inhibitory peptides: structure-activity relationship study on peptide chemical properties, terminal preferences and intracellular regulation of melanogenesis …

PG Yap, CY Gan - Biochimica et Biophysica Acta (BBA)-General Subjects, 2024 - Elsevier
Background Bioactive peptides have gained attention as potential alternatives to chemical-
based skin lightening agents. Based on literature search, the reported articles focused …

Cancer Diagnostics and early detection using Electrochemical Aptasensors

JI Omage, E Easterday, JT Rumph, I Brula, B Hill… - Micromachines, 2022 - mdpi.com
The detection of early-stage cancer offers patients the best chance of treatment and could
help reduce cancer mortality rates. However, cancer cells or biomarkers are present in …

In Silico identification of angiotensin-converting enzyme inhibitory peptides from MRJP1

RA Tahir, A Bashir, MN Yousaf, A Ahmed, Y Dali… - PloS one, 2020 - journals.plos.org
Hypertension is considered as one of the most common diseases that affect human beings
(both male and female) due to its high prevalence and also extending widely to both …