The liver has a multitude of functions which are necessary to maintain whole body
homeostasis. This requires that various metabolic pathways can run in parallel in the most …

Cancer dissemination and metastasis is synonymous with invasive cell migration; a process
in which the extracellular matrix (ECM) plays the dual role of the substratum on which the …

Plants have evolved to synthesize a variety of noxious compounds to cope with unfavorable
circumstances, among which a large group of toxic proteins that play a critical role in plant …

Ribosome-inactivating proteins (RIPs) are EC3. 2.32. 22 N-glycosidases that recognize a
universally conserved stem-loop structure in 23S/25S/28S rRNA, depurinating a single …

Urokinase plasminogen activator receptor (uPAR) binds pro-urokinase plasminogen
activator (pro-uPA) and thereby localizes it near plasminogen, causing the generation of …

Simple Summary Discovered more than three decades ago, the urokinase-type
plasminogen activator receptor (uPAR) has now firmly established itself as a versatile …

The term ribosome-inactivating protein (RIP) is used to denominate proteins mostly of plant
origin, which have N-glycosidase enzymatic activity leading to a complete destruction of the …

Plant ribosome-inactivating protein (RIP) toxins are EC3. 2.2. 22 N-glycosidases, found
among most plant species encoded as small gene families, distributed in several tissues …

The glycolipid-anchored receptor for urokinase-type plasminogen activator (uPAR) is
essential for cell-surface associated plasminogen activation and is overexpressed at the …

Type I ribosome inactivating proteins such as saporin from the plant Saponaria officinalis L.
are widely used as toxin moieties of targeted anti-tumor toxins. For exerting cytotoxicity the …