Self-driving laboratories (SDLs) promise an accelerated application of the scientific method.
Through the automation of experimental workflows, along with autonomous experimental …

The therapeutic properties of plants have been recognised since time immemorial. Many
pathological conditions have been treated using plant-derived medicines. These medicines …

Small-molecule drug discovery can be viewed as a challenging multidimensional problem in
which various characteristics of compounds—including efficacy, pharmacokinetics and …

DNA-encoded chemical libraries (DELs) have emerged as a powerful technology in drug
discovery. The wide adoption of DELs in the pharmaceutical industry and the rapid …

Click chemistry, proposed nearly 20 years ago, promised access to novel chemical space by
empowering combinatorial library synthesis with a “few good reactions”. These click …

Several combinatorial methods have been developed to create focused or diverse chemical
libraries with a wide range of linear or macrocyclic chemical molecules: peptides, non …

The development of bioactive small molecules as probes or drug candidates requires
discovery platforms that enable access to chemical diversity and can quickly reveal new …

Emerging threats to human health require a concerted effort in search of both preventive and
treatment strategies, placing natural products at the center of efforts to obtain new therapies …

In two decades of development, impressive strides have been made for automating basic
laboratory operations in droplet-based microfluidics, allowing the emergence of a new form …

Microfluidic droplet sorting enables the high‐throughput screening and selection of water‐in‐
oil microreactors at speeds and volumes unparalleled by traditional well‐plate approaches …