The use of general anesthetics in modern clinical practice is commonly regarded as safe for
healthy individuals, but exposures at the extreme ends of the age spectrum have been …

Brain development is a dynamic and lengthy process that includes cell proliferation,
migration, neurogenesis, gliogenesis, synaptogenesis, and pruning. Disruption of any of …

Sevoflurane is commonly used in clinical anesthesia. However, some reports indicated that
Sevoflurane could induce mitochondrial injury and neuroapoptosis. Although the …

Background Sevoflurane (sevo) has been reported to be an effective neuroprotective agent
in cerebral ischemia/reperfusion injury (CIRI). However, the precise molecular mechanism …

General anesthesia is a powerful and indispensable tool to ensure the accomplishment of
surgical procedures or clinical examinations. Sevoflurane as an inhalational anesthetic …

The mechanism of anesthesia neurotoxicity remains largely to be determined. The effects of
long noncoding RNAs (LncRNAs) on neural differentiation and the underlying mechanisms …

For decades, the neurotoxicity caused by anesthetics in mammalian brain development has
gained increasing attention. Exposure to anesthetics leads to neurotoxicity and apoptosis of …

Objective Sevoflurane is a common anesthetic and is widely used in pediatric clinical
surgery to induce and maintain anesthesia through inhalation. Increasing studies have …

Background Postoperative cognitive dysfunction (POCD) is a neurodegenerative disorder
with impairment of cognition. Sevoflurane anesthesia has been found to lead to CD and …

Postoperative cognitive dysfunction (POCD) is a frequent neurological complication
encountered during the perioperative period with unclear mechanisms and no effective …