Chronic kidney disease (CKD) is a long-term condition in which the kidneys do not work
correctly. It has a high prevalence and represents a serious hazard to human health and …

The understanding of renal fibrosis in chronic kidney disease (CKD) remains as a challenge.
More than 10% of the population of developed countries suffer from CKD. Proliferation and …

Introduction Diabetic nephropathy (DN) is a form of progressive kidney disease that often
leads to end-stage renal disease (ESRD). It is initiated by microvascular complications due …

Over recent years routine ultrasound scanning has identified increasing numbers of
neonates as having hydronephrosis and pelvi-ureteric junction obstruction (PUJO). This …

Background Vascular calcification is associated with increased cardiovascular morbidity and
mortality in patients with atherosclerosis, diabetes and chronic kidney disease. However, no …

Many different regulatory mechanisms of renal fibrosis are known to date, and those related
to transforming growth factor-β1 (TGF-β1)-induced signaling have been studied in greater …

Nucleic acid medicine is expected to be among the most promising next-generation
therapies. Applications of nucleic acid in vivo are still challenging as a result of the …

Background: Angiotensin-converting enzyme 2 (ACE2) deletion worsens kidney injury, and
its amplification ameliorates diabetic nephropathy. Male sex increases the incidence …

The involvement of Ras‐GTPases in the development of renal fibrosis has been addressed
in the last decade. We have previously shown that H‐and N‐Ras isoforms participate in the …

Ras proteins regulate cell survival, growth, differentiation, blood pressure, and fibrosis in
some organs. We have demonstrated that H‐ras gene deletion produces mice hypotension …