Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

Significance: Protein S-nitrosylation, the oxidative modification of cysteine by nitric oxide
(NO) to form protein S-nitrosothiols (SNOs), mediates redox-based signaling that conveys, in …

For decades, the major focus of redox biology has been oxygen, the most abundant element
on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial …

Abstract S-nitrosoglutathione reductase (GSNOR), or ADH5, is an enzyme in the alcohol
dehydrogenase (ADH) family. It is unique when compared to other ADH enzymes in that …

Modification of cysteine residues by oxidative and nitrosative stress affects structure and
function of proteins, thereby contributing to the pathogenesis of cardiovascular disease …

The free radical nitric oxide (NO•) regulates diverse physiological processes from
vasodilation in humans to gas exchange in plants. S-Nitrosoglutathione (GSNO) is …

Background: S-nitrosylation (SNO), a prototypic redox-based posttranslational modification,
is involved in the pathogenesis of cardiovascular disease. The aim of this study was to …

Evidence exists that heart failure (HF) has an overall impact of 1-2% in the global population
being often associated with comorbidities that contribute to increased disease prevalence …

Immune targeted therapy of nitric oxide (NO) synthases are being considered as a potential
frontline therapeutic to treat patients diagnosed with locally advanced and metastatic …

The S-nitrosoglutathione reductase (GSNOR) is a key denitrosating enzyme that regulates
protein S-nitrosation, a process which has been found to be involved in the pathogenesis of …