Helping koalas battle disease – Recent advances in Chlamydia and koala retrovirus (KoRV) disease understanding and treatment in koalas

BL Quigley, P Timms - FEMS Microbiology Reviews, 2020 - academic.oup.com
The iconic Australian marsupial, the koala (Phascolarctos cinereus), has suffered dramatic
population declines as a result of habitat loss and fragmentation, disease, vehicle collision …

Endogenous retroviruses drive resistance and promotion of exogenous retroviral homologs

ES Chiu, S VandeWoude - Annual Review of Animal …, 2021 - annualreviews.org
Endogenous retroviruses (ERVs) serve as markers of ancient viral infections and provide
invaluable insight into host and viral evolution. ERVs have been exapted to assist in …

The piRNA response to retroviral invasion of the koala genome

T Yu, BS Koppetsch, S Pagliarani, S Johnston… - Cell, 2019 - cell.com
Summary Antisense Piwi-interacting RNAs (piRNAs) guide silencing of established
transposons during germline development, and sense piRNAs drive ping-pong amplification …

Retroviral integrations contribute to elevated host cancer rates during germline invasion

GK McEwen, DE Alquezar-Planas, A Dayaram… - Nature …, 2021 - nature.com
Repeated retroviral infections of vertebrate germlines have made endogenous retroviruses
ubiquitous features of mammalian genomes. However, millions of years of evolution obscure …

Koala retrovirus genetic diversity and transmission dynamics within captive koala populations

BA Joyce, MDJ Blyton, SD Johnston… - Proceedings of the …, 2021 - National Acad Sciences
Koala populations are currently in rapid decline across Australia, with infectious diseases
being a contributing cause. The koala retrovirus (KoRV) is a gammaretrovirus present in …

Koala retrovirus genotyping analyses reveal a low prevalence of KoRV-A in Victorian koalas and an association with clinical disease

AR Legione, JLS Patterson… - Journal of medical …, 2017 - microbiologyresearch.org
Purpose. Koala retrovirus (KoRV) is undergoing endogenization into the genome of koalas
in Australia, providing an opportunity to assess the effect of retrovirus infection on the health …

Molecular dynamics and mode of transmission of koala retrovirus as it invades and spreads through a wild Queensland koala population

BL Quigley, VA Ong, J Hanger, P Timms - Journal of Virology, 2018 - Am Soc Microbiol
The recent acquisition of a novel retrovirus (KoRV) by koalas (Phascolarctos cinereus) has
created new opportunities for retroviral research and new challenges for koala conservation …

Koala immunogenetics and chlamydial strain type are more directly involved in chlamydial disease progression in koalas from two south east Queensland koala …

A Robbins, J Hanger, M Jelocnik, BL Quigley… - Scientific Reports, 2020 - nature.com
Chlamydial disease control is increasingly utilised as a management tool to stabilise
declining koala populations, and yet we have a limited understanding of the factors that …

Envelope Recombination: A Major Driver in Shaping Retroviral Diversification and Evolution within the Host Genome

S Chabukswar, N Grandi, LT Lin, E Tramontano - Viruses, 2023 - mdpi.com
Endogenous retroviruses (ERVs) are integrated into host DNA as the result of ancient germ
line infections, primarily by extinct exogenous retroviruses. Thus, vertebrates' genomes …

Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions

MDJ Blyton, PR Young, BD Moore… - Proceedings of the …, 2022 - National Acad Sciences
Koala retrovirus (KoRV) subtype A (KoRV-A) is currently in transition from exogenous virus
to endogenous viral element, providing an ideal system to elucidate retroviral–host …