[HTML][HTML] T helper (Th) cell profiles in pregnancy and recurrent pregnancy losses: Th1/Th2/Th9/Th17/Th22/Tfh cells

W Wang, N Sung, A Gilman-Sachs… - Frontiers in …, 2020 - frontiersin.org
During pregnancy, various immune effectors and molecules participating in the immune-
microenvironment establish specific maternal tolerance toward the semi-allogeneic fetus …

[HTML][HTML] Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection

SS Pinho, I Alves, J Gaifem… - Cellular & Molecular …, 2023 - nature.com
The immune system is coordinated by an intricate network of stimulatory and inhibitory
circuits that regulate host responses against endogenous and exogenous insults. Disruption …

Turning'sweet'on immunity: galectin–glycan interactions in immune tolerance and inflammation

GA Rabinovich, MA Toscano - Nature Reviews Immunology, 2009 - nature.com
The function of deciphering the biological information encoded by the glycome, which is the
entire repertoire of complex sugar structures expressed by cells and tissues, is assigned in …

[HTML][HTML] Mammalian glycosylation in immunity

JD Marth, PK Grewal - Nature Reviews Immunology, 2008 - nature.com
Glycosylation produces a diverse and abundant repertoire of glycans, which are collectively
known as the glycome. Glycans are one of the four fundamental macromolecular …

Galectin-1: a jack-of-all-trades in the resolution of acute and chronic inflammation

V Sundblad, LG Morosi, JR Geffner… - The Journal of …, 2017 - journals.aai.org
Regulatory signals provide negative input to immunological networks promoting resolution
of acute and chronic inflammation. Galectin-1 (Gal-1), a member of a family of evolutionarily …

Galectins: regulators of acute and chronic inflammation

FT Liu, GA Rabinovich - Annals of the New York Academy of …, 2010 - Wiley Online Library
Galectins, β‐galactoside‐binding animal lectins, are differentially expressed by various
immune cells as well as a wide range of other cell types. Extracellularly, galectins are able to …

Nanotopographical control of stem cell differentiation

LE McNamara, RJ McMurray… - Journal of tissue …, 2010 - journals.sagepub.com
Stem cells have the capacity to differentiate into various lineages, and the ability to reliably
direct stem cell fate determination would have tremendous potential for basic research and …

The role of galectins as modulators of metabolism and inflammation

MF Brinchmann, DM Patel… - Mediators of …, 2018 - Wiley Online Library
Galectins are β‐galcotosid‐binding lectins. The function of galectins varies with their tissue‐
specific and subcellular location, and their binding to carbohydrates makes them key players …

Galectins in innate immunity: dual functions of host soluble β‐galactoside‐binding lectins as damage‐associated molecular patterns (DAMPs) and as receptors for …

S Sato, C St‐Pierre, P Bhaumik… - Immunological …, 2009 - Wiley Online Library
The glycocalyx is a glycan layer found on the surfaces of host cells as well as
microorganisms and enveloped virus. Its thickness may easily exceed 50 nm. The …

Galectin-1: a link between tumor hypoxia and tumor immune privilege

QT Le, G Shi, H Cao, DW Nelson, Y Wang… - Journal of clinical …, 2005 - ascopubs.org
Purpose To identify a 15-KDa novel hypoxia-induced secreted protein in head and neck
squamous cell carcinomas (HNSCC) and to determine its role in malignant progression …