Immunogenicity of CAR-T cell therapeutics: evidence, mechanism and mitigation

AN Khan, A Chowdhury, A Karulkar… - Frontiers in …, 2022 - frontiersin.org
Chimeric antigen receptor T cell (CAR-T) therapy demonstrated remarkable success in long-
term remission of cancers and other autoimmune diseases. Currently, six products (Kymriah …

CAR-T cell potency: from structural elements to vector backbone components

M Mazinani, F Rahbarizadeh - Biomarker research, 2022 - Springer
Chimeric antigen receptor (CAR) T cell therapy, in which a patient's own T lymphocytes are
engineered to recognize and kill cancer cells, has achieved remarkable success in some …

Mechanisms of action and limitations of monoclonal antibodies and single chain fragment variable (scFv) in the treatment of cancer

C Rodríguez-Nava, C Ortuño-Pineda, B Illades-Aguiar… - Biomedicines, 2023 - mdpi.com
Monoclonal antibodies are among the most effective tools for detecting tumor-associated
antigens. The US Food and Drug Administration (FDA) has approved more than 36 …

[HTML][HTML] Enhanced antitumor efficacy, proliferative capacity, and alleviation of T cell exhaustion by fifth-generation chimeric antigen receptor T cells targeting B cell …

P Yuti, N Sawasdee, K Natungnuy… - Biomedicine & …, 2023 - Elsevier
Chimeric antigen receptor (CAR) T cell therapy targeting B cell maturation antigen (BCMA)
has been approved for treating multiple myeloma (MM). Some clinical studies reported …

[HTML][HTML] Cytotoxicity of fourth-generation anti-Trop2 CAR-T cells against breast cancer

C Somboonpatarakun, N Phanthaphol… - International …, 2024 - Elsevier
The treatment of breast cancer (BC) remains a formidable challenge due to the emergence
of drug resistance, necessitating the exploration of innovative strategies. Chimeric antigen …

Alpha-mangostin inhibits viral replication and suppresses nuclear factor kappa B (NF-κB)-mediated inflammation in dengue virus infection

M Tarasuk, P Songprakhon, T Chieochansin… - Scientific Reports, 2022 - nature.com
Severe dengue virus (DENV) infection results from viral replication and dysregulated host
immune response, which trigger massive cytokine production/cytokine storm. The result is …

Challenges and strategies associated with CAR-T cell therapy in blood malignancies

Z Liu, W Lei, H Wang, X Liu, R Fu - Experimental Hematology & Oncology, 2024 - Springer
Cellular immunotherapy, particularly CAR-T cells, has shown potential in the improvement of
outcomes in patients with refractory and recurrent malignancies of the blood. However …

[HTML][HTML] Anti-CD19 chimeric antigen receptor T cells secreting anti-PD-L1 single-chain variable fragment attenuate PD-L1 mediated T cell inhibition

P Yuti, Y Wutti-In, N Sawasdee, K Kongkhla… - International …, 2022 - Elsevier
Adoptive T cell therapy using second-generation anti-CD19 chimeric antigen receptor T
cells (anti-CD19-CAR2-T) induced complete remission in many heavily pretreated patients …

ICOS and OX40 tandem co-stimulation enhances CAR T-cell cytotoxicity and promotes T-cell persistence phenotype

E Moreno-Cortes, P Franco-Fuquen… - Frontiers in …, 2023 - frontiersin.org
Chimeric Antigen Receptor (CAR) T-cell therapies have emerged as an effective and
potentially curative immunotherapy for patients with relapsed or refractory malignancies …

Molecular and therapeutic effect of CRISPR in treating cancer

S Rodrigo, K Senasinghe, S Quazi - Medical Oncology, 2023 - Springer
Cancer has become one of the common causes of mortality around the globe due to
mutations in the genome which allows rapid growth of cells uncontrollably without repairing …