Placental control of drug delivery

S Al-Enazy, S Ali, N Albekairi, M El-Tawil… - Advanced drug delivery …, 2017 - Elsevier
The placenta serves as the interface between the maternal and fetal circulations and
regulates the transfer of oxygen, nutrients, and waste products. When exogenous …

The role of xenobiotic-metabolizing enzymes in the placenta: a growing research field

R Blanco-Castañeda… - Expert review of …, 2020 - Taylor & Francis
Introduction: The placenta is a temporary and unique organ that allows for the physical
connection between a mother and fetus; this organ regulates the transport of gases and …

Exposure to selective noradrenalin reuptake inhibitors during the first trimester of pregnancy and risk of congenital malformations: A meta-analysis of cohort studies

ZQ Lou, YY Zhou, X Zhang, HY Jiang - Psychiatry Research, 2022 - Elsevier
Selective serotonin-noradrenalin reuptake inhibitors (SNRIs) are used to treat depression
and anxiety during pregnancy; however, information regarding their foetal safety is limited …

[HTML][HTML] Altered activities of CYP1A1 and CYP19A1 enzymes in women using SSRI medication during pregnancy

H Sahlman, A Itkonen, M Lehtonen, L Keski-Nisula… - Placenta, 2022 - Elsevier
Introduction Selective serotonin reuptake inhibitors (SSRIs) are commonly used medication
for the treatment of depression during pregnancy. Their use may affect various biological …

Assessment of the inhibitory activity of the pyrethroid pesticide deltamethrin against human placental glutathione transferase P1-1: a combined kinetic and docking …

V Markus, K Teralı, O Dalmizrak, N Ozer - Environmental Toxicology and …, 2018 - Elsevier
Deltamethrin (DEL), which is a synthetic pyrethroid insecticide, has been used successfully
all over the world to treat mosquito nets for the control of malaria. Glutathione S-transferases …

Mechanistic insights into the inhibition of human placental glutathione S‐transferase P1‐1 by abscisic and gibberellic acids: An integrated experimental and …

MA Zaid, O Dalmizrak, K Teralı… - Journal of Molecular …, 2023 - Wiley Online Library
The interactions of the classic phytohormones gibberellic acid (gibberellin A3, GA3) and
abscisic acid (dormin, ABA), which antagonistically regulate several developmental …

Susceptibility to the acute toxicity of acrylonitrile in streptozotocin-induced diabetic rats: Protective effect of phenethyl isothiocyanate, a phytochemical CYP2E1 …

F Li, Y Dong, R Lu, B Yang, S Wang… - Drug and Chemical …, 2021 - Taylor & Francis
Diabetes mellitus is a significant global public health issue. The diabetic state not only
precipitates chronic disease but also has the potential to change the toxicity of drugs and …

The Inhibition of Glutathione S-Transferases and Butyrylcholinesterase by Antidepressants: A Mini-Review on Enzyme-Drug Interactions

V Markus, Ö Dalmızrak, K Teralı… - Current Enzyme …, 2022 - ingentaconnect.com
Background: Compromises in the cellular enzymatic defense barrier can increase the
duration of exposure to electrophiles and the severity of toxicity they may incur. Objective: In …

[PDF][PDF] SciVerse ScienceDirect

V Markus, K Teralı, O Dalmizrak, N Ozer - researchgate.net
Deltamethrin (DEL), which is a synthetic pyrethroid insecticide, has been used successfully
all over the world to treat mosquito nets for the control of malaria. Glutathione S-transferases …

[PDF][PDF] HUMAN PLACENTAL GLUTATHIONE S-TRANSFERASE P1-1 (hpGSTP1-1): INHIBITORY ACTIVITY AND MOLECULAR DOCKING STUDIES OF …

V MARKUS - docs.neu.edu.tr
Glutathione transferases (EC 2.5. 1.18, referred also as Glutathione S-transferases, GSTs)
are a significant large family of enzymes, primarily responsible for the phase II detoxification …