The lack of safe and efficient gene-delivery methods is a limiting obstacle to human gene
therapy. Synthetic gene-delivery agents, although safer than recombinant viruses, generally …

The continually increasing wealth of knowledge about the role of genes involved in acquired
or hereditary diseases renders the delivery of regulatory genes or nucleic acids into affected …

Offering the latest information in magnetic nanoparticle (MNP) research, Magnetic
Nanoparticles: From Fabrication to Clinical Applications provides a comprehensive review …

Recent evidence suggests that the airway mucus gel layer may be impermeable to the viral
and synthetic gene vectors used in past inhaled gene therapy clinical trials for diseases like …

The strategy of using mesenchymal stem cells (MSCs) as a living carrier for active delivery of
therapeutic agents targeting tumor sites has been attempted in a wide range of studies to …

Respiratory gene therapy has been considered for the treatment of a broad range of
pulmonary disorders. However, respiratory secretions form an important barrier towards the …

Nanomedicine is a multidisciplinary research field with an integration of traditional sciences
such as chemistry, physics, biology and materials science. The application of nanomedicine …

Engineering polymeric gene-delivery vectors to release an intact DNA payload at the
optimal time and subcellular compartment remains a formidable challenge. An ideal vector …

Cystic fibrosis (CF), the most prevalent, fatal genetic disorder in the Caucasian population, is
caused by mutations of CF transmembrane conductance regulator (CFTR). The mutations of …

Gene therapy aimed at the respiratory epithelium holds therapeutic potential for diseases
such as cystic fibrosis and lung cancer. Polyethylenimine (PEI) has been utilized for gene …