Interleukins and associated cytokines serve as the means of communication for innate and
adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a …

Cytokines are highly inducible, secretory proteins that mediate intercellular communication
in the immune system. They are grouped into several protein families that are referred to as …

Bone is a common site of metastasis in lung cancer, but the regulatory mechanism remains
incompletely understood. Osteoclasts are known to play crucial roles in osteolytic bone …

Abstract The interleukin-20 (IL-20) subfamily of cytokines comprises IL-19, IL-20, IL-22, IL-24
and IL-26. These cytokines are all members of the larger IL-10 family, but have been …

Abstract The Interleukin (IL)-10 cytokine family includes IL-10, IL-19, IL-20, IL-22, IL-24, and
IL-26, which are considered as Class 2α-helical cytokines. IL-10 is the most important …

Rationale: Tumor microenvironment interacts with tumor cells to regulate their stemness
properties through various cytokines and cytokine receptors. Previous studies revealed the …

Pancreatic ductal adenocarcinoma (PDAC) and cancer-associated cachexia (CAC) are
multifactorial and characterized by dysregulated inflammatory networks. Whether the …

Abstract Interleukin-22 (IL-22) is an IL-10 family cytokine produced by T cells and innate
lymphoid cells. The IL-22 signaling pathway orchestrates mucosal immune defense and …

In breast cancer, an uncontrolled cell proliferation leads to tumor formation and development
of a multifactorial disease. Metastasis is a complex process that involves tumor spread to …

Cancer, a common malignant disease, is one of the predominant causes of diseases that
lead to death. Additionally, cancer is often detected in advanced stages and cannot be …