In higher eukaryotes, enhancers determine the activation of developmental gene
transcription in specific cell types and stages of embryogenesis. Enhancers transform the …

In higher eukaryotes, the regulation of developmental gene expression is determined by
enhancers, which are often located at a large distance from the promoters they regulate …

Chromatin looping is key to gene regulation, yet no broadly applicable methods to
selectively modify chromatin loops have been described. We have engineered a method for …

The three-dimensional arrangement of the human genome comprises a complex network of
structural and regulatory chromatin loops important for coordinating changes in transcription …

Induction of fetal hemoglobin (HbF) via clustered regularly interspaced short palindromic
repeats/Cas9–mediated disruption of DNA regulatory elements that repress γ-globin gene …

Chromatin loops enable transcription-factor-bound distal enhancers to interact with their
target promoters to regulate transcriptional programs. Although developmental transcription …

The spatial organization of chromosomes is involved in regulating the majority of
intranuclear processes in higher eukaryotes, including gene expression. Drosophila was …

Fetal haemoglobin (HbF, α2γ2) induction has long been an area of investigation, as it is
known to ameliorate the clinical complications of sickle cell disease (SCD). Progress in …

Simple Summary The physical interactions between enhancers and promoters create
chromatin conformations involved in gene regulation. In cancer cells, the chromatin …

The eukaryotic genome is organized at varying levels into chromosome territories,
transcriptional compartments and topologically associating domains (TADs), which are …