The glymphatic system: implications for drugs for central nervous system diseases

TJ Lohela, TO Lilius, M Nedergaard - Nature Reviews Drug Discovery, 2022 - nature.com
In the past decade, evidence for a fluid clearance pathway in the central nervous system
known as the glymphatic system has grown. According to the glymphatic system concept …

Non‐Cartesian parallel imaging reconstruction

KL Wright, JI Hamilton, MA Griswold… - Journal of Magnetic …, 2014 - Wiley Online Library
Non‐Cartesian parallel imaging has played an important role in reducing data acquisition
time in MRI. The use of non‐Cartesian trajectories can enable more efficient coverage of k …

Ultra-fast magnetic resonance encephalography of physiological brain activity–glymphatic pulsation mechanisms?

V Kiviniemi, X Wang, V Korhonen… - Journal of Cerebral …, 2016 - journals.sagepub.com
The theory on the glymphatic convection mechanism of cerebrospinal fluid holds that
cardiac pulsations in part pump cerebrospinal fluid from the peri-arterial spaces through the …

Human NREM sleep promotes brain-wide vasomotor and respiratory pulsations

H Helakari, V Korhonen, SC Holst… - Journal of …, 2022 - Soc Neuroscience
The physiological underpinnings of the necessity of sleep remain uncertain. Recent
evidence suggests that sleep increases the convection of cerebrospinal fluid (CSF) and …

Cardiovascular brain impulses in Alzheimer's disease

Z Rajna, H Mattila, N Huotari, T Tuovinen, J Krüger… - Brain, 2021 - academic.oup.com
Accumulation of amyloid-β is a key neuropathological feature in brain of Alzheimer's disease
patients. Alterations in cerebral haemodynamics, such as arterial impulse propagation …

[HTML][HTML] Content-Free Awareness: EEG-fcMRI Correlates of Consciousness as Such in an Expert Meditator

U Winter, P LeVan, TL Borghardt, B Akin… - Frontiers in …, 2020 - frontiersin.org
The minimal neural correlate of the conscious state, regardless of the neural activity
correlated with the ever-changing contents of experience, has still not been identified …

[HTML][HTML] Sampling rate effects on resting state fMRI metrics

N Huotari, L Raitamaa, H Helakari, J Kananen… - Frontiers in …, 2019 - frontiersin.org
Low image sampling rates used in resting state functional magnetic resonance imaging (rs-
fMRI) may cause aliasing of the cardiorespiratory pulsations over the very low frequency …

[HTML][HTML] The variability of functional MRI brain signal increases in Alzheimer's disease at cardiorespiratory frequencies

T Tuovinen, J Kananen, Z Rajna, J Lieslehto… - Scientific Reports, 2020 - nature.com
Biomarkers sensitive to prodromal or early pathophysiological changes in Alzheimer's
disease (AD) symptoms could improve disease detection and enable timely interventions …

Real-time fMRI for brain-computer interfacing

B Sorger, R Goebel - Handbook of clinical neurology, 2020 - Elsevier
Brain-computer interfaces (BCIs) based on functional magnetic resonance imaging (fMRI)
provide an important complement to other noninvasive BCIs. While fMRI has several …

[HTML][HTML] Increased very low frequency pulsations and decreased cardiorespiratory pulsations suggest altered brain clearance in narcolepsy

M Järvelä, J Kananen, V Korhonen, N Huotari… - Communications …, 2022 - nature.com
Background Narcolepsy is a chronic neurological disease characterized by daytime sleep
attacks, cataplexy, and fragmented sleep. The disease is hypothesized to arise from …