Epithelial–mesenchymal plasticity (EMP) plays critical roles during embryonic development,
wound repair, fibrosis, inflammation and cancer. During cancer progression, EMP results in …

Considerable progress has been made in identifying microenvironmental signals that effect
the reversible phenotypic transitions underpinning the early steps in the metastatic cascade …

Leukemia Inhibitory Factor (LIF) is a member of the IL-6 cytokine family and is expressed in
almost every tissue type within the body. Although LIF was named for its ability to induce …

Tumorigenesis and metastasis have deep connections to inflammation and inflammatory
cytokines, but the mechanisms underlying these relationships are poorly understood …

Cancer stem cells (CSCs) present chemo-resistance mechanisms contributing to tumour
maintenance and recurrence, making their targeting of utmost importance in gastric cancer …

The dysregulation of leukemia inhibitory factor (LIF) and its cognate receptor (LIFR) has
been associated with multiple cancer initiation, progression, and metastasis. LIF plays a …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive, treatment-resistant
cancer. Five-year survival rate is about 9%, one of the lowest among all solid tumors. Such a …

Leukemia inhibitory factor (LIF) is a pleiotropic cytokine with several functions in health and
disease ranging from inflammation to cancer. LIF is also a potential target and/or therapeutic …

IL-6 family cytokine leukaemia inhibitory factor (LIF) study has deciphered a variety of
effects, in physiology as well as pathology. Despite the sudden arousal in LIF interest in …

Purpose Chordomas are highly therapy-resistant primary bone tumors that exhibit high
relapse rates and may induce local destruction. Here, we evaluated the effects of tumor …