Sirtuins, a promising target in slowing down the ageing process
W Grabowska, E Sikora, A Bielak-Zmijewska - Biogerontology, 2017 - Springer
Ageing is a plastic process and can be successfully modulated by some biomedical
approaches or pharmaceutics. In this manner it is possible to delay or even prevent some …
approaches or pharmaceutics. In this manner it is possible to delay or even prevent some …
The multifaceted functions of sirtuins in cancer
A Chalkiadaki, L Guarente - Nature Reviews Cancer, 2015 - nature.com
The sirtuins (SIRTs; of which there are seven in mammals) are NAD+-dependent enzymes
that regulate a large number of cellular pathways and forestall the progression of ageing …
that regulate a large number of cellular pathways and forestall the progression of ageing …
SIRT7: the seventh key to unlocking the mystery of aging
Aging is a chronic yet natural physiological decline of the body. Throughout life, humans are
continuously exposed to a variety of exogenous and endogenous stresses, which engender …
continuously exposed to a variety of exogenous and endogenous stresses, which engender …
Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility
C Tatone, G Di Emidio, A Barbonetti… - Human …, 2018 - academic.oup.com
Abstract BACKGROUND Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases
that catalyze post-translational modifications of proteins. Together, they respond to …
that catalyze post-translational modifications of proteins. Together, they respond to …
An overview of Sirtuins as potential therapeutic target: Structure, function and modulators
Y Wang, J He, M Liao, M Hu, W Li, H Ouyang… - European journal of …, 2019 - Elsevier
Abstract Sirtuin (Yeast Silent Information RegulatorsⅡ, Sir2) was first discovered in the
1970s. Because of its function by removing acetylated groups from histones in the presence …
1970s. Because of its function by removing acetylated groups from histones in the presence …
[HTML][HTML] Nucleolar organizer regions: genomic 'dark matter'requiring illumination
B McStay - Genes & development, 2016 - genesdev.cshlp.org
Nucleoli form around tandem arrays of a ribosomal gene repeat, termed nucleolar organizer
regions (NORs). During metaphase, active NORs adopt a characteristic undercondensed …
regions (NORs). During metaphase, active NORs adopt a characteristic undercondensed …
SIRT 7 promotes genome integrity and modulates non‐homologous end joining DNA repair
Sirtuins, a family of protein deacetylases, promote cellular homeostasis by mediating
communication between cells and environment. The enzymatic activity of the mammalian …
communication between cells and environment. The enzymatic activity of the mammalian …
SIRT7 in the aging process
FA Lagunas-Rangel - Cellular and Molecular Life Sciences, 2022 - Springer
Aging is the result of the accumulation of a wide variety of molecular and cellular damage
over time. This has been associated with a number of features termed hallmarks of aging …
over time. This has been associated with a number of features termed hallmarks of aging …
[HTML][HTML] Sirtuin regulation in aging and injury
N Poulose, R Raju - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2015 - Elsevier
Sirtuins or Sir2 family of proteins are a class of NAD+ dependent protein deacetylases which
are evolutionarily conserved from bacteria to humans. Some sirtuins also exhibit mono-ADP …
are evolutionarily conserved from bacteria to humans. Some sirtuins also exhibit mono-ADP …
A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function
Mitochondrial activity is controlled by proteins encoded by both nuclear and mitochondrial
DNA. Here, we identify Sirt7 as a crucial regulator of mitochondrial homeostasis. Sirt7 …
DNA. Here, we identify Sirt7 as a crucial regulator of mitochondrial homeostasis. Sirt7 …