ABSTRACT TACC3 is the most oncogenic member of the transforming acidic coiled-coil
domain-containing protein (TACC) family. It is one of the major recruitment factors of distinct …

TACC3 regulates spindle organization during mitosis and also regulates centrosome‐
mediated microtubule nucleation by affecting γ‐Tubulin ring complexes. In addition, it …

Background E2F1 is a transcription factor that regulates cell cycle progression. It is highly
expressed in most cancer cells and activates transcription of cell cycle-related kinases …

The integration of genomic and DNA methylation data has been demonstrated as a powerful
strategy in understanding cancer mechanisms and identifying therapeutic targets. The TCGA …

TACC3, a transforming acidic coiled-coil (TACC) family member, is frequently upregulated in
a broad spectrum of cancers, including breast cancer. It plays critical roles in protecting …

Renal cell carcinoma (RCC) is one of the most aggressive urologic cancers, however, the
mechanism on supporting RCC carcinogenesis is still not clear. By using gene expression …

Growing evidence has demonstrated that transforming acidic coiled-coil protein 3 (TACC3),
a member of the TACC family, may be involved in regulating cell mitosis, transcription, and …

The mitotic spindle, essential for segregating the sister chromatids into the two evolving
daughter cells, is composed of highly dynamic cytoskeletal filaments, the microtubules. The …

Detection of disseminated tumor cells (DTCs) in bone marrow is an established negative
prognostic factor. We isolated small pools of (~ 20) EPCAM-positive DTCs from early breast …

Abstract Trastuzumab emtansine (T-DM1) was the first and one of the most successful
antibody–drug conjugates (ADC) approved for treating refractory HER2-positive breast …