Osteoporotic fractures lead to increased disability and mortality in the elderly population.
With the rapid increase in the aging population around the globe, more effective treatments …

Osteoporosis is the second most common disease only secondary to cardiovascular
disease, with the risk of fracture increasing with age. Osteoporosis is caused by an …

Clinical evidence has established that concomitant traumatic brain injury (TBI) accelerates
bone healing, but the underlying mechanism is unclear. This study shows that after TBI …

Aims The involvement of several microRNAs (miRNAs) in osteogenic differentiation has
been indicated recently. Also, exosomes, derived from different cells, could shuttle specific …

Exosomes, as messengers of cell‐to‐cell communication, have many functional properties
similar to those of their derived cells. Because they contain a large number of bioactive …

The maintenance of bone homeostasis includes both bone resorption by osteoclasts and
bone formation by osteoblasts. These two processes are in dynamic balance to maintain a …

Bone remodeling represents a physiological phenomenon of continuous bone tissue
renewal that requires fine orchestration of multiple cell types, which is critical for the …

This review showcases miRNAs contributing to the regulation of bone forming osteoblasts
through their effects on the TGFβ and BMP pathways, with a focus on ligands, receptors and …

Aging is associated with an increased incidence of age-related bone diseases. Current
diagnostics (eg, conventional radiology, biochemical markers), because limited in specificity …

Extracellular vesicles (EVs) are nanoparticles that include exosomes, microvesicles, and
apoptotic bodies; they interact with target cell surface receptors and transport contents …