Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes
Hypercontractility of arterial myocytes and enhanced vascular tone during diabetes are, in
part, attributed to the effects of increased glucose (hyperglycemia) on L-type CaV1. 2 …
part, attributed to the effects of increased glucose (hyperglycemia) on L-type CaV1. 2 …
Voltage-gated Cav1 channels in disorders of vision and hearing
MA Joiner, A Lee - Current molecular pharmacology, 2015 - ingentaconnect.com
Cav1 channels mediate L-type Ca2+ currents that trigger the exocytotic release of glutamate
from the specialized “ribbon” synapse of retinal photoreceptors (PRs) and cochlear inner …
from the specialized “ribbon” synapse of retinal photoreceptors (PRs) and cochlear inner …
Elementary properties of CaV1.3 Ca2+ channels expressed in mouse cochlear inner hair cells
V Zampini, SL Johnson, C Franz… - The Journal of …, 2010 - Wiley Online Library
Mammalian cochlear inner hair cells (IHCs) are specialized to process developmental
signals during immature stages and sound stimuli in adult animals. These signals are …
signals during immature stages and sound stimuli in adult animals. These signals are …
[HTML][HTML] AGs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia
Elevated glucose increases vascular reactivity by promoting L-type CaV1. 2 channel (LTCC)
activity by protein kinase A (PKA). Yet, how glucose activates PKA is unknown. We …
activity by protein kinase A (PKA). Yet, how glucose activates PKA is unknown. We …
Exocytotic machineries of vestibular type I and cochlear ribbon synapses display similar intrinsic otoferlin-dependent Ca2+ sensitivity but a different coupling to Ca2+ …
PFY Vincent, Y Bouleau, S Safieddine… - Journal of …, 2014 - Soc Neuroscience
The hair cell ribbon synapses of the mammalian auditory and vestibular systems differ
greatly in their anatomical organization and firing properties. Notably, vestibular Type I hair …
greatly in their anatomical organization and firing properties. Notably, vestibular Type I hair …
Release from the cone ribbon synapse under bright light conditions can be controlled by the opening of only a few Ca2+ channels
TM Bartoletti, SL Jackman, N Babai… - Journal of …, 2011 - journals.physiology.org
Light hyperpolarizes cone photoreceptors, causing synaptic voltage-gated Ca2+ channels to
open infrequently. To understand neurotransmission under these conditions, we determined …
open infrequently. To understand neurotransmission under these conditions, we determined …
[HTML][HTML] K+ accumulation and clearance in the calyx synaptic cleft of type I mouse vestibular hair cells
P Spaiardi, E Tavazzani, M Manca, G Russo, I Prigioni… - Neuroscience, 2020 - Elsevier
Vestibular organs of Amniotes contain two types of sensory cells, named Type I and Type II
hair cells. While Type II hair cells are contacted by several small bouton nerve terminals …
hair cells. While Type II hair cells are contacted by several small bouton nerve terminals …
[HTML][HTML] Fine Tuning of CaV1.3 Ca2+ Channel Properties in Adult Inner Hair Cells Positioned in the Most Sensitive Region of the Gerbil Cochlea
V Zampini, SL Johnson, C Franz, M Knipper… - PloS one, 2014 - journals.plos.org
Hearing relies on faithful signal transmission by cochlear inner hair cells (IHCs) onto
auditory fibres over a wide frequency and intensity range. Exocytosis at IHC ribbon …
auditory fibres over a wide frequency and intensity range. Exocytosis at IHC ribbon …
An allosteric gating model recapitulates the biophysical properties of IK,L expressed in mouse vestibular type I hair cells
P Spaiardi, E Tavazzani, M Manca… - The Journal of …, 2017 - Wiley Online Library
Key points Vestibular type I and type II hair cells and their afferent fibres send information to
the brain regarding the position and movement of the head. The characteristic feature of type …
the brain regarding the position and movement of the head. The characteristic feature of type …
Responses of pigeon vestibular hair cells to cholinergic agonists and antagonists
GQ Li, MJ Correia - Brain research, 2011 - Elsevier
Acetylcholine (ACh) is the major neurotransmitter released from vestibular efferent terminals
onto hair cells and afferents. Previous studies indicate that the two classes of acetylcholine …
onto hair cells and afferents. Previous studies indicate that the two classes of acetylcholine …