The development of cancer is due to the accumulation of multiple somatic mutations and in
some cases due to germline mutations, which occur in malignancies such as retinoblastoma …

Purpose To update the recommendations for the use of tumor marker tests in the prevention,
screening, treatment, and surveillance of breast cancer. Methods For the 2007 update, an …

One of the benefits of Digital PCR (dPCR) is the potential for unparalleled precision
enabling smaller fold change measurements. An example of an assessment that could …

The gene known as neu, erbB-2, or HER-2 is among those most frequently altered in human
cancer, neu was first identified as a transforming gene activated in chemically induced rat …

The HER2 proto‐oncogene encodes a transmembrane glycoprotein of 185 kDa
(p185HER2) with intrinsic tyrosine kinase activity. Amplification of the HER2 gene and …

Breast cancer emerges by a multistep process which can be broadly equated to
transformation of normal cells via the steps of hyperplasia, premalignant change and in situ …

Neoadjuvant chemotherapy (NAC) for breast cancer is evolving and subsequent adjuvant
systemic treatment is mainly based on the presence of the Estrogen (ER) receptor …

PURPOSE: c-erbB-2 (HER-2, c-neu) might play a role as a predictive factor in breast cancer.
However, the clinical utility of the marker in this disease is still not established. We …

This book explains and reviews some of the significant events involved in human
implantation and the establishment of the placenta in the uterus. This critical phase in …

1. INTRODUCTION The present invention relates to novel compounds capable of
modulating. regulating and/or inhibiting tyrosine kinase signal transduction. The present …