The pH of the tumor microenvironment drives the metastatic phenotype and
chemotherapeutic resistance of tumors. Understanding the mechanisms underlying this pH …

The tumor microenvironment includes a complicated network of physiological gradients
contributing to plasticity of tumor cells and heterogeneity of tumor tissue. Hypoxia is a key …

Esophageal adenocarcinoma (EAC) has a dismal prognosis, and survival benefits of recent
multimodality treatments remain small. Cancer-associated fibroblasts (CAFs) are known to …

Background: The functional interplay between tumor cells and their adjacent stroma has
been suggested to play crucial roles in the initiation and progression of tumors and the …

Esophageal cancer (EC) is one of the most life-threatening malignancies worldwide.
Esophageal squamous cell carcinoma (ESCC) is the dominant subtype, accounting for …

Purpose In this systematic review, the existing evidence of available hypoxia-associated
molecular response biomarkers in esophageal cancer (EC) patients is summarized and set …

Esophageal cancer (EC) is the eighth most common type of cancer and the sixth leading
cause of cancer-related deaths worldwide. At present, the clinical treatment for EC is based …

Fibroblasts are known as critical stromal cells in wound healing by synthesizing extracellular
matrix and collagen. A subpopulation of them is called cancer-associated fibroblasts (CAFs) …

Esophageal cancer (EC) is the sixth most deadly cancer, and its incidence is still increasing
year by year. Although the researches on the molecular mechanisms of EC have been …

Background Monocarboxylate transporters (MCTs) are cell membrane proteins which
transport pyruvate, lactate and ketone bodies across the plasma membrane. MCTs are …