High-performance medicine: the convergence of human and artificial intelligence

EJ Topol - Nature medicine, 2019 - nature.com
The use of artificial intelligence, and the deep-learning subtype in particular, has been
enabled by the use of labeled big data, along with markedly enhanced computing power …

Spectral-domain OCT measurements in Alzheimer's disease: a systematic review and meta-analysis

VTT Chan, Z Sun, S Tang, LJ Chen, A Wong, CC Tham… - Ophthalmology, 2019 - Elsevier
Topic OCT is a noninvasive tool to measure specific retinal layers in the eye. The
relationship of retinal spectral-domain (SD) OCT measurements with Alzheimer's disease …

A foundation model for generalizable disease detection from retinal images

Y Zhou, MA Chia, SK Wagner, MS Ayhan… - Nature, 2023 - nature.com
Medical artificial intelligence (AI) offers great potential for recognizing signs of health
conditions in retinal images and expediting the diagnosis of eye diseases and systemic …

Key challenges for delivering clinical impact with artificial intelligence

CJ Kelly, A Karthikesalingam, M Suleyman, G Corrado… - BMC medicine, 2019 - Springer
Background Artificial intelligence (AI) research in healthcare is accelerating rapidly, with
potential applications being demonstrated across various domains of medicine. However …

Objectives, design and main findings until 2020 from the Rotterdam Study

MA Ikram, G Brusselle, M Ghanbari… - European journal of …, 2020 - Springer
Abstract The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in
the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical …

Predicting sex from retinal fundus photographs using automated deep learning

E Korot, N Pontikos, X Liu, SK Wagner, L Faes… - Scientific reports, 2021 - nature.com
Deep learning may transform health care, but model development has largely been
dependent on availability of advanced technical expertise. Herein we present the …

Retinal imaging in Alzheimer's and neurodegenerative diseases

PJ Snyder, J Alber, C Alt, LJ Bain… - Alzheimer's & …, 2021 - Wiley Online Library
In the last 20 years, research focused on developing retinal imaging as a source of potential
biomarkers for Alzheimer's disease and other neurodegenerative diseases, has increased …

Insights into systemic disease through retinal imaging-based oculomics

SK Wagner, DJ Fu, L Faes, X Liu… - … vision science & …, 2020 - tvst.arvojournals.org
Among the most noteworthy developments in ophthalmology over the last decade has been
the emergence of quantifiable high-resolution imaging modalities, which are typically non …

Leveraging physiology and artificial intelligence to deliver advancements in health care

A Zhang, Z Wu, E Wu, M Wu, MP Snyder… - Physiological …, 2023 - journals.physiology.org
Artificial intelligence in health care has experienced remarkable innovation and progress in
the last decade. Significant advancements can be attributed to the utilization of artificial …

[HTML][HTML] Alzheimer's disease pathophysiology in the retina

BP Gaire, Y Koronyo, DT Fuchs, H Shi… - Progress in Retinal and …, 2024 - Elsevier
The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …