From strings to signals: Unraveling the impact of miRNAs on diagnosis, and progression of colorectal cancer
OA Mohammed - Pathology-Research and Practice, 2023 - Elsevier
Colorectal cancer (CRC) stands as the third most prevalent ailment globally and represents
the primary cause of mortality associated with cancer. Significant advancements have been …
the primary cause of mortality associated with cancer. Significant advancements have been …
[HTML][HTML] Comprehensive review of potential drugs with anti-pulmonary fibrosis properties
J Ma, G Li, H Wang, C Mo - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Pulmonary fibrosis is a chronic and progressive lung disease characterized by the
accumulation of scar tissue in the lungs, which leads to impaired lung function and reduced …
accumulation of scar tissue in the lungs, which leads to impaired lung function and reduced …
Alvespimycin exhibits potential anti-TGF-β signaling in the setting of a proteasome activator in rats with bleomycin-induced pulmonary fibrosis: a promising novel …
Idiopathic pulmonary fibrosis (IPF) is an irreversible and life-threatening lung disease of
unknown etiology presenting only a few treatment options. TGF-β signaling orchestrates a …
unknown etiology presenting only a few treatment options. TGF-β signaling orchestrates a …
[HTML][HTML] Innovative challenge for the inhibition of hepatocellular carcinoma progression by combined targeting of HSP90 and STAT3/HIF-1α signaling
S Saber, EE Abd El-Fattah, AM Abdelhamid… - Biomedicine & …, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is the third foremost cause of cancer-related deaths. HCC
has a very bad prognosis because it is asymptomatic in the early stages, resulting in a late …
has a very bad prognosis because it is asymptomatic in the early stages, resulting in a late …
STA9090 as a potential therapeutic agent for liver fibrosis by modulating the HSP90/TβRII/proteasome interplay: novel insights from in vitro and in vivo investigations
Liver fibrosis is a progressive condition characterized by the build-up of fibrous tissue
resulting from long-term liver injury. Although there have been advancements in research …
resulting from long-term liver injury. Although there have been advancements in research …
Itraconazole halts hepatocellular carcinoma progression by modulating sonic hedgehog signaling in rats: A novel therapeutic approach
Liver cancer stands as the fourth leading global cause of death, and its prognosis remains
grim due to the limited effectiveness of current medical interventions. Among the various …
grim due to the limited effectiveness of current medical interventions. Among the various …
Nifuroxazide mitigates doxorubicin-induced cardiovascular injury: Insight into oxidative/NLRP3/GSDMD-mediated pyroptotic signaling modulation
Doxorubicin (DOX) is a widely used powerful anthracycline for treatment of many varieties of
malignancies; however its cumulative and dose-dependent cardio-toxicity has been limited …
malignancies; however its cumulative and dose-dependent cardio-toxicity has been limited …
[HTML][HTML] Mirtazapine, an atypical antidepressant, mitigates lung fibrosis by suppressing NLPR3 inflammasome and fibrosis-related mediators in endotracheal …
Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible lung disease with a poor
prognosis. There is currently no definitive cure for IPF. The present study establishes a …
prognosis. There is currently no definitive cure for IPF. The present study establishes a …
Alogliptin exhibits multifaceted effects in thioacetamide-insulted rats: a novel approach to combating hepatic inflammation and fibrogenesis
OA Mohammed - Pathology-Research and Practice, 2023 - Elsevier
Hepatic fibrosis arising from chronic liver injury is characterized by dysregulated healing,
including hepatic stellate cell activation and excessive deposition of extracellular matrix …
including hepatic stellate cell activation and excessive deposition of extracellular matrix …
Lung cancer treatment potential and limits associated with the STAT family of transcription factors
P Faida, MKI Attiogbe, U Majeed, J Zhao, L Qu, D Fan - Cellular Signalling, 2023 - Elsevier
Lung cancer is one of the mortal cancers and the leading cause of cancer-related mortality,
with a cancer survival rate of fewer than 5% in developing nations. This low survival rate can …
with a cancer survival rate of fewer than 5% in developing nations. This low survival rate can …