From strings to signals: Unraveling the impact of miRNAs on diagnosis, and progression of colorectal cancer

OA Mohammed - Pathology-Research and Practice, 2023 - Elsevier
Colorectal cancer (CRC) stands as the third most prevalent ailment globally and represents
the primary cause of mortality associated with cancer. Significant advancements have been …

[HTML][HTML] Comprehensive review of potential drugs with anti-pulmonary fibrosis properties

J Ma, G Li, H Wang, C Mo - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Pulmonary fibrosis is a chronic and progressive lung disease characterized by the
accumulation of scar tissue in the lungs, which leads to impaired lung function and reduced …

Alvespimycin exhibits potential anti-TGF-β signaling in the setting of a proteasome activator in rats with bleomycin-induced pulmonary fibrosis: a promising novel …

OA Mohammed, MA Abdel-Reheim, LA Saleh… - Pharmaceuticals, 2023 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is an irreversible and life-threatening lung disease of
unknown etiology presenting only a few treatment options. TGF-β signaling orchestrates a …

[HTML][HTML] Innovative challenge for the inhibition of hepatocellular carcinoma progression by combined targeting of HSP90 and STAT3/HIF-1α signaling

S Saber, EE Abd El-Fattah, AM Abdelhamid… - Biomedicine & …, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is the third foremost cause of cancer-related deaths. HCC
has a very bad prognosis because it is asymptomatic in the early stages, resulting in a late …

STA9090 as a potential therapeutic agent for liver fibrosis by modulating the HSP90/TβRII/proteasome interplay: novel insights from in vitro and in vivo investigations

OA Mohammed, MA Abdel-Reheim, MMS Alamri… - Pharmaceuticals, 2023 - mdpi.com
Liver fibrosis is a progressive condition characterized by the build-up of fibrous tissue
resulting from long-term liver injury. Although there have been advancements in research …

Itraconazole halts hepatocellular carcinoma progression by modulating sonic hedgehog signaling in rats: A novel therapeutic approach

OA Mohammed, AS Doghish, LA Saleh… - … -Research and Practice, 2024 - Elsevier
Liver cancer stands as the fourth leading global cause of death, and its prognosis remains
grim due to the limited effectiveness of current medical interventions. Among the various …

Nifuroxazide mitigates doxorubicin-induced cardiovascular injury: Insight into oxidative/NLRP3/GSDMD-mediated pyroptotic signaling modulation

FM Amin, MH Sharawy, MN Amin, M El-Sherbiny… - Life Sciences, 2023 - Elsevier
Doxorubicin (DOX) is a widely used powerful anthracycline for treatment of many varieties of
malignancies; however its cumulative and dose-dependent cardio-toxicity has been limited …

[HTML][HTML] Mirtazapine, an atypical antidepressant, mitigates lung fibrosis by suppressing NLPR3 inflammasome and fibrosis-related mediators in endotracheal …

R Abdelhady, S Cavalu, S Saber, R Elmowafy… - Biomedicine & …, 2023 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible lung disease with a poor
prognosis. There is currently no definitive cure for IPF. The present study establishes a …

Alogliptin exhibits multifaceted effects in thioacetamide-insulted rats: a novel approach to combating hepatic inflammation and fibrogenesis

OA Mohammed - Pathology-Research and Practice, 2023 - Elsevier
Hepatic fibrosis arising from chronic liver injury is characterized by dysregulated healing,
including hepatic stellate cell activation and excessive deposition of extracellular matrix …

Lung cancer treatment potential and limits associated with the STAT family of transcription factors

P Faida, MKI Attiogbe, U Majeed, J Zhao, L Qu, D Fan - Cellular Signalling, 2023 - Elsevier
Lung cancer is one of the mortal cancers and the leading cause of cancer-related mortality,
with a cancer survival rate of fewer than 5% in developing nations. This low survival rate can …