Non-tuberculous mycobacteria cause a broad range of clinical disorders, from cutaneous
infections, such as cervical or intrathoracic lymphadenitis in children, to disseminated …

Abstract Pediatric Coronavirus Disease 2019 (pCOVID-19) is rarely severe; however, a
minority of children infected with severe acute respiratory syndrome coronavirus 2 (SARS …

Anticytokine autoantibodies are an emerging mechanism of disease in previously healthy
adults. Patients with these syndromes demonstrate a unique infectious phenotype …

INTRODUCTION Studies of monogenic diseases have uncovered the importance of immune
pathways in human tissue-specific immunity and antimicrobial defense. In particular, human …

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare
primary immunodeficiency disorder typically caused by homozygous AIRE mutations. It …

Background Autoantibodies against interferon-γ are associated with severe disseminated
opportunistic infection, but their importance and prevalence are unknown. Methods We …

BACKGROUND: Mutations in signal transducer and activator of transcription (STAT) 1 cause
a broad spectrum of disease, ranging from severe viral and bacterial infections (amorphic …

Cryptococcal meningitis has been described in immunocompromised patients, as well as in
those for whom no immune defect has been identified. GM-CSF regulates the function of …

Cryptococcosis is caused by either Cryptococcus neoformans or C. gattii. While cryptococcal
meningoencephalitis is caused mostly by C. neoformans in immunocompromised patients …

Background The natural history of anti-interferon-γ (IFN-γ) autoantibody-associated
immunodeficiency syndrome is not well understood. Methods Data of 74 patients with anti …