Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies

S Paul, E Candelario-Jalil - Experimental neurology, 2021 - Elsevier
Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

Remote ischaemic conditioning—a new paradigm of self-protection in the brain

DC Hess, RA Blauenfeldt, G Andersen… - Nature Reviews …, 2015 - nature.com
Remote ischaemic conditioning (RIC) triggers endogenous protective pathways in distant
organs such as the kidney, heart and brain, and represents an exciting new paradigm in …

Endothelial cell-derived exosomes protect SH-SY5Y nerve cells against ischemia/reperfusion injury

B Xiao, Y Chai, S Lv, M Ye, M Wu… - International …, 2017 - spandidos-publications.com
Cerebral ischemia is a leading cause of death and disability. A previous study indicated that
remote ischemic postconditioning (RIP) in the treatment of cerebral ischemia reduces …

Effect of in-hospital remote ischemic perconditioning on brain infarction growth and clinical outcomes in patients with acute ischemic stroke: the RESCUE BRAIN …

F Pico, B Lapergue, M Ferrigno, C Rosso… - JAMA …, 2020 - jamanetwork.com
Importance Treatment with remote ischemic perconditioning has been reported to reduce
brain infarction volume in animal models of stroke. Whether this neuroprotective effect was …

Ischemic conditioning-induced endogenous brain protection: applications pre-, per-or post-stroke

Y Wang, C Reis, R Applegate II, G Stier, R Martin… - Experimental …, 2015 - Elsevier
In the area of brain injury and neurodegenerative diseases, a plethora of experimental and
clinical evidence strongly indicates the promise of therapeutically exploiting the endogenous …

The role of peripheral monocytes and macrophages in ischemic stroke

D Han, H Liu, Y Gao - Neurological Sciences, 2020 - Springer
After acute ischemic stroke (AIS), peripheral monocytes infiltrate into the lesion site within 24
h, peak at 3 to 7 days, and then differentiate into macrophages. Traditionally, monocytes …

Limb remote ischemic conditioning: mechanisms, anesthetics, and the potential for expanding therapeutic options

G Chen, M Thakkar, C Robinson, S Doré - Frontiers in neurology, 2018 - frontiersin.org
Novel and innovative approaches are essential in developing new treatments and improving
clinical outcomes in patients with ischemic stroke. Remote ischemic conditioning (RIC) is a …

Remote ischemic postconditioning: harnessing endogenous protection in a murine model of vascular cognitive impairment

MB Khan, MN Hoda, K Vaibhav, S Giri, P Wang… - Translational stroke …, 2015 - Springer
We previously reported that remote limb ischemic conditioning (RLIC; PERconditioning)
during acute stroke confers neuroprotection, possibly due to increased cerebral blood flow …

Review cerebral ischemic tolerance and preconditioning: methods, mechanisms, clinical applications, and challenges

Y Hao, M Xin, L Feng, X Wang, X Wang, D Ma… - Frontiers in …, 2020 - frontiersin.org
Stroke is one of the leading causes of morbidity and mortality worldwide, and it is increasing
in prevalence. The limited therapeutic window and potential severe side effects prevent the …

Preclinical evidence of remote ischemic conditioning in ischemic stroke, a metanalysis update

C Torres-Querol, M Quintana-Luque, G Arque… - Scientific reports, 2021 - nature.com
Remote ischemic conditioning (RIC) is a promising therapeutic approach for ischemic stroke
patients. It has been proven that RIC reduces infarct size and improves functional outcomes …