Targeting and readout strategies for fast optical neural control in vitro and in vivo
V Gradinaru, KR Thompson, F Zhang… - Journal of …, 2007 - Soc Neuroscience
Major obstacles faced by neuroscientists in attempting to unravel the complexity of brain
function include both the heterogeneity of brain tissue (with a multitude of cell types present …
function include both the heterogeneity of brain tissue (with a multitude of cell types present …
The appropriate use of neurostimulation: new and evolving neurostimulation therapies and applicable treatment for chronic pain and selected disease states
TR Deer, E Krames, N Mekhail, J Pope, M Leong… - … : Technology at the …, 2014 - Elsevier
Introduction: The International Neuromodulation Society (INS) has determined that there is a
need to provide an expert consensus that defines the appropriate use of neuromodulation …
need to provide an expert consensus that defines the appropriate use of neuromodulation …
[HTML][HTML] Molecular and cellular approaches for diversifying and extending optogenetics
Optogenetic technologies employ light to control biological processes within targeted cells in
vivo with high temporal precision. Here, we show that application of molecular trafficking …
vivo with high temporal precision. Here, we show that application of molecular trafficking …
Bi-stable neural state switches
Here we describe bi-stable channelrhodopsins that convert a brief pulse of light into a stable
step in membrane potential. These molecularly engineered probes nevertheless retain …
step in membrane potential. These molecularly engineered probes nevertheless retain …
eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications
V Gradinaru, KR Thompson, K Deisseroth - Brain cell biology, 2008 - Springer
Temporally precise inhibition of distinct cell types in the intact nervous system has been
enabled by the microbial halorhodopsin NpHR, a fast light-activated electrogenic Cl− pump …
enabled by the microbial halorhodopsin NpHR, a fast light-activated electrogenic Cl− pump …
Structure of the light-driven chloride pump halorhodopsin at 1.8 Å resolution
M Kolbe, H Besir, LO Essen, D Oesterhelt - Science, 2000 - science.org
Halorhodopsin, an archaeal rhodopsin ubiquitous in Haloarchaea, uses light energy to
pump chloride through biological membranes. Halorhodopsin crystals were grown in a cubic …
pump chloride through biological membranes. Halorhodopsin crystals were grown in a cubic …
Optical control of zebrafish behavior with halorhodopsin
AB Arrenberg, F Del Bene… - Proceedings of the …, 2009 - National Acad Sciences
Expression of halorhodopsin (NpHR), a light-driven microbial chloride pump, enables
optical control of membrane potential and reversible silencing of targeted neurons. We …
optical control of membrane potential and reversible silencing of targeted neurons. We …
Light-sensitive ion-passing molecules
2011-10-12 Assigned to THE BOARD OF TRUSTEES OF THE LELAND STANFORD
JUNIOR UNIVERSITY reassignment THE BOARD OF TRUSTEES OF THE LELAND …
JUNIOR UNIVERSITY reassignment THE BOARD OF TRUSTEES OF THE LELAND …
[HTML][HTML] Analogies between halorhodopsin and bacteriorhodopsin
G Váró - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2000 - Elsevier
The light-activated proton-pumping bacteriorhodopsin and chloride ion-pumping
halorhodopsin are compared. They belong to the family of retinal proteins, with 25% amino …
halorhodopsin are compared. They belong to the family of retinal proteins, with 25% amino …
Temperature and halide dependence of the photocycle of halorhodopsin from Natronobacterium pharaonis
I Chizhov, M Engelhard - Biophysical journal, 2001 - cell.com
The photocycle kinetics of halorhodopsin from Natronobacterium pharaonis (pHR 575) was
analyzed at different temperatures and chloride concentrations as well as various halides …
analyzed at different temperatures and chloride concentrations as well as various halides …